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Identification and assessment of pathogenicity of a naturally reassorted infectious bursal disease virus from Henan, China.
Poultry Science ( IF 4.4 ) Pub Date : 2019-12-01 , DOI: 10.3382/ps/pez498 Qiuxia Wang 1, 2 , Huilong Hu 2 , Guangli Chen 3 , Hailin Liu 3 , Siyuan Wang 2 , Dasong Xia 2 , Yan Yu 2 , Yanhong Zhang 2 , Jinqing Jiang 2 , Jinyou Ma 2 , Yanzhao Xu 2 , Zhiyong Xu 2 , Changbo Ou 2 , Xingyou Liu 1, 2
Poultry Science ( IF 4.4 ) Pub Date : 2019-12-01 , DOI: 10.3382/ps/pez498 Qiuxia Wang 1, 2 , Huilong Hu 2 , Guangli Chen 3 , Hailin Liu 3 , Siyuan Wang 2 , Dasong Xia 2 , Yan Yu 2 , Yanhong Zhang 2 , Jinqing Jiang 2 , Jinyou Ma 2 , Yanzhao Xu 2 , Zhiyong Xu 2 , Changbo Ou 2 , Xingyou Liu 1, 2
Affiliation
Infectious bursal disease virus (IBDV) is still a vital etiological agent in poultry farms. IBDV outbreaks occasionally occur due to the presence of very virulent, reassortment or variant strains. Vaccine immunization has played crucial roles in IBD control for decades. However, survival pressure of IBDV from the vaccine immunization also increases the reassortments of circulating viruses. In this study, an IBDV strain was isolated from several broiler farms in Henan Province, central part of China, and named IBDV HN strain. Based on the results of RT-PCR, sequencing and phylogenic analyses of VP1 and VP2 genes, the IBDV HN strain is a novel reassortment strain in the Henan region. Segment A of this strain appears to originate from the very virulent IBDV strain, while segment B comes from the other field reassortment strains. This may be the result of natural reassortant of virus circulating in the field. About 60% (6/10) of experimentally infected specific pathogen-free chickens died after 3 to 5 d post-infection with typical symptom and pathological lesions. The IBDV HN strain was prone to horizontal transmission, which poses a serious threat to the chicken industry. Further investigation on the prevalence, virulence, and evolution of HN strain IBDV will provide a foundation for the prevention and control of the disease in this region.
更新日期：2020-04-17
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