PURPOSE To determine the distribution and quantity of ophthalmic viscosurgical device (OVD) retained in the lens capsular bag after irrigation/aspiration (I/A) in experimental cataract surgery. SETTING Department of Ophthalmology, Kashiwa Hospital, Jikei University School of Medicine, Japan. DESIGN Experimental study. METHODS Fifteen freshly enucleated porcine eyes were used. Sodium hyaluronate 1.0% (Healon) was mixed with a fixed concentration of silica nanoparticles encapsulating fluorescein isothiocyanate (labeled OVD), and it was injected separately into the capsular bag and injector cartridge for intraocular lens (IOL) insertion. After a 3-piece IOL (YA-60BBR) or a 1-piece IOL (iSert 255) was implanted within the capsular bag, OVD was removed by thorough I/A. Eyes that were injected with the labeled OVD into the capsular bag without IOL insertion were used as controls. The distribution of residual OVD in the capsular bag was observed under ultraviolet irradiation using Miyake-Apple view. Then, the excised capsular bag was dissolved in hydrogen fluoride, and silica concentration was measured quantitatively by elemental analysis. RESULTS The quantity of residual OVD in the capsular bag was 243.1 μg ± 1.3 (SD) in the 3-piece IOL-implanted group, 383.8 ± 11.1 μg in the 1-piece IOL-implanted group, and 99.0 ± 1.3 μg in the control group. In the 1-piece IOL-implanted eyes, OVD in the form of clumps tended to remain near the center of the optic on the posterior side, and the quantity of residual OVD was significantly greater than in 3-piece IOL-implanted eyes (P < .05). CONCLUSION The quantity of residual OVD after I/A could be determined indirectly using labeled OVD, and the quantity was significantly greater in 1-piece IOL-implanted eyes than in 3-piece IOL-implanted eyes.

中文翻译：

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体外实验白内障手术冲洗/抽吸后定量残留眼科内窥镜手术设备。

目的确定在实验性白内障手术中冲洗/抽吸（I / A）后保留在晶状体囊膜袋中的眼科内窥镜手术器械（OVD）的分布和数量。设置日本经济科学大学医学院柏市医院眼科。设计实验研究。方法使用15只新鲜去核猪眼。将1.0％的透明质酸钠（Healon）与固定浓度的封装有异硫氰酸荧光素的二氧化硅纳米颗粒（标记为OVD）混合，然后将其分别注入囊袋和注射器盒中以插入人工晶状体（IOL）。将3片IOL（YA-60BBR）或1片IOL（iSert 255）植入囊袋后，通过彻底的I / A去除OVD。在未插入IOL的情况下，将带有标记的OVD注入囊袋的眼用作对照。使用Miyake-Apple视图在紫外线照射下观察到囊袋中残留OVD的分布。然后，将切下的囊袋溶解在氟化氢中，并且通过元素分析定量地测量二氧化硅浓度。结果3片人工晶状体植入组的囊袋中残留OVD量为243.1μg±1.3（SD），1片人工晶状体植入组为383.8±11.1μg，对照组为99.0±1.3μg团体。在1块人工晶状体植入眼中，以团块形式出现的OVD倾向于保留在后视镜中央附近，并且残留OVD的数量明显大于3块人工晶状体植入眼（P <.05）。