Abstract To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentration of released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research.

中文翻译：

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用于癌症治疗中药物亚细胞递送的多功能纳米平台

摘要 为了实现对疾病的高效治疗，将带有载体的药物成功递送到特定细胞器（细胞核、线粒体、溶酶体等）中具有重要意义。基于纳米颗粒 (NP) 的药物递送系统 (NDDS) 的靶向递送主要集中在细胞膜靶向。在这篇综述中，我们总结了多功能纳米颗粒细胞器特异性药物递送的研究。通过改变它们的化学成分或通过将官能团接枝到它们的表面以提高细胞器靶向能力，引入了许多有效的策略来使这些 NPs 功能化。只有当释放的药物浓度足够高时，它们才会与特定细胞器上的分子靶点相互作用，从而诱导肿瘤细胞凋亡。