Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis.,The Journal of Antibiotics

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Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2019-08-26 , DOI: 10.1038/s41429-019-0223-7
Zahra Khosravi Babadi _{1,

2} , Enge Sudarman _{3,

4} , Gholam Hossein Ebrahimipour ₁ , Gian Primahana _{3,

4} , Marc Stadler _{3,

4} , Joachim Wink _{2,

4}

Affiliation

The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC₅₀ value of 5.4 µM.

更新日期：2020-01-17

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