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ER Stress Priming of Mitochondrial Respiratory suPERKomplex Assembly
Trends in Endocrinology & Metabolism ( IF 10.9 ) Pub Date : 2019-10-01 , DOI: 10.1016/j.tem.2019.08.003
Ruben Quintana-Cabrera 1 , Maria Eugenia Soriano 2
Affiliation  

Assembly factors are necessary for the formation of mitochondrial supercomplexes (SCs) and in making cellular respiration more efficient. In a recent study, Balsa et al. (Mol. Cell, 2019) report that nutrient-induced endoplasmic reticulum (ER) stress engages PERK-eIF2α-mediated transcription of the SCs assembly factor SCAF1, events that coordinate ER stress and SCs formation to improve bioenergetics.

中文翻译:

线粒体呼吸超复合体组装的内质网应激启动

组装因子对于线粒体超级复合物 (SC) 的形成和使细胞呼吸更有效是必需的。在最近的一项研究中,巴尔萨等人。(Mol. Cell, 2019) 报告说,营养诱导的内质网 (ER) 应激参与了 PERK-eIF2α 介导的 SCs 组装因子 SCAF1 的转录,这些事件协调了 ER 应激和 SCs 形成以改善生物能量学。
更新日期:2019-10-01
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