Although the mechanisms underlying the formation of intestinal fibrostrictures in Crohn’s disease [CD] are not fully understood, activation of fibroblasts and excessive collagen deposition are supposed to contribute to the development of such complications. Here, we investigated the role of cadherin-11 [CDH-11], a fibroblast-derived protein that induces collagen production in various organs, in intestinal fibrosis.

中文翻译：

---

Cadherin-11是肠道纤维化的调节剂

尽管尚未完全了解克罗恩病[CD]中肠纤维缩窄形成的机制，但据信成纤维细胞的活化和胶原蛋白的过度沉积有助于此类并发症的发展。在这里，我们研究了钙黏着蛋白11 [CDH-11]（一种成纤维细胞蛋白，在各个器官中诱导胶原蛋白生成）在肠道纤维化中的作用。