Tibial dyschondroplasia (TD) is an intractable tibiotarsal bone disorder of rapid growing avian species, which leads to huge economic losses and compromised poultry welfare. However, the exact pathogenesis and treatment of TD remain largely unknown. Based on continuous research findings, we propose the TD pathogenesis hypothesis: during skeletal development of TD chickens, due to the absence of vasculature of proximal tibial growth plates (TGP), hypertrophic chondrocytes of the TGP are unable to complete calcification in normal bone development and less dead chondrocytes in the corresponding area can be timely transported through the blood vessels. Moreover, recent studies demonstrate that the TD formation mechanism gradually tends to a large number of dead chondrocytes in the TGP region or apoptosis occur due to various factors (such as, reduction of vascular invasion and blood cells, and increased weight or mechanical force of the tibia), while the reduction of blood vessels is insufficient to remove these chondrocytes and eventually leads to the TD formation. Recognizing the possible role of the blood vessels in the incidence of TD and can propose that the improvement in vasculature might be a novel therapeutic approach for ending TD in chickens.

中文翻译：

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血管在肉鸡胫骨软骨发育不良中的作用。

胫骨软骨发育不良（TD）是快速生长的鸟类的一种顽固性胫跗骨疾病，会导致巨大的经济损失和家禽福利。然而，TD的确切发病机制和治疗仍然很大程度上未知。基于不断的研究发现，我们提出TD发病机制假说：在TD鸡骨骼发育过程中，由于胫骨近端生长板（TGP）血管系统的缺失，TGP的肥大软骨细胞在正常骨骼发育过程中无法完成钙化，相应区域死​​亡的软骨细胞较少，可以及时通过血管转运。此外，最近的研究表明，由于多种因素（如，血管侵入和血细胞减少，胫骨重量或机械力增加），而血管的减少不足以去除这些软骨细胞并最终导致 TD 形成。认识到血管在 TD 发病率中的可能作用，并可以提出血管系统的改善可能是结束鸡 TD 的一种新的治疗方法。