The nuclear organelle the nucleolus and the transcription factor nuclear factor of κ-light-chain-enhancer of activated B cells (NF-κB) are both central to the control of cellular homeostasis, dysregulated in common diseases and implicated in the ageing process. Until recently, it was believed that they acted independently to regulate homeostasis in health and disease. However, there is an emerging body of evidence suggesting that nucleoli and NF-κB signalling converge at multiple levels. Here we will review current understanding of this crosstalk. We will discuss activation of the NF-κB pathway by nucleolar stress and induction of apoptosis by nucleolar sequestration of NF-κB/RelA. We will also discuss the role of TIF-IA, COMMD1, and nucleophosmin, which are key players in this crosstalk, and the therapeutic relevance, particularly with respect to the antitumour effects of aspirin.

中文翻译：

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洞察核仁压力与NF-κB通路之间的关系。

激活的B细胞（NF-κB）κ轻链增强子的核仁和转录因子核因子（NF-κB）都是控制细胞稳态的关键，在常见疾病中失调并涉及衰老过程。直到最近，人们还认为它们在调节健康和疾病中的体内平衡方面起着独立的作用。但是，越来越多的证据表明核仁和NF-κB信号在多个水平上会聚。在这里，我们将回顾对这种串扰的当前理解。我们将讨论核仁胁迫对NF-κB通路的激活以及核仁螯合NF-κB/ RelA对细胞凋亡的诱导。我们还将讨论TIF-IA，COMMD1和核磷蛋白（在这种串扰中的关键作用）的作用以及治疗意义，