The global prevalence of obesity continues to increase, suggesting a need for alternative treatment approaches. Targeting brown fat function to promote energy expenditure represents one such approach. Brown adipocytes and the related beige adipocytes oxidize fatty acids and glucose to generate heat and are activated by cold exposure or consumption of high-calorie diets. Alternative, more practical means to activate thermogenic fat are needed. Here, we review emerging data suggesting new roles for lipids in activating thermogenesis that extend beyond their serving as a fuel source for heat generation. Lipids have also been implicated in mediating interorgan communication, crosstalk between organelles, and cellular signaling regulating thermogenesis. Understanding how lipids regulate thermogenesis could identify innovative therapeutic interventions for obesity.

中文翻译：

---

产热脂肪激活的脂质调节剂

肥胖症的全球流行率继续增加，这表明需要替代治疗方法。针对棕色脂肪功能以促进能量消耗就是这样一种方法。棕色脂肪细胞和相关的米色脂肪细胞氧化脂肪酸和葡萄糖以产生热量，并被冷暴露或高热量饮食的消耗激活。需要替代的、更实用的方法来激活产热脂肪。在这里，我们回顾了新出现的数据，这些数据表明脂质在激活产热方面的新作用超出了它们作为热量产生的燃料来源的作用。脂质还涉及介导器官间通讯、细胞器之间的串扰和调节产热的细胞信号传导。