The leaves and bark of Syringa oblata Lindl are used as folk medicine which has heat-clearing, detoxifying, dampness-removing and jaundice-relieving effects. There are many studies about leaves of S. oblata because of its abundant resource, however, less reports about the components of S. oblata flowers. The previous studies on S. oblate flowers were mainly focused on the volatile components and its traditional pharmacological activity. Thus, this study aimed to investigate the nonvolatile chemical constituents and the coagulation activity of S. oblate flowers. The chemical constituents of S. oblate flowers were isolated with various column chromatographies and coagulation activity of the major constituents was investigated by assaying the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) on plasma of rabbit in vitro. Fifteen known compounds (namely compound 1-15) were isolated from S. oblata flowers. Compound 6, 10, 11 and 14 were isolated from Syringa genus for the first time. Compound 1, 2, 4, 5, 8 and 9 were isolated from the plant for the first time. The results of coagulation activity showed that water part of S. oblate flowers, lauric acid and kaempferol-rutinose significantly shorten PT (P < 0.001), TT (P < 0.001) and APTT (P < 0.001) compared with blank group, thus revealed that water extract of S. oblate flowers, lauric acid and kaempferol-rutinose possessed the procoagulant activity, but the effects were not better than that of Yunnan Baiyao as positive control.

中文翻译：

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紫丁香花的化学成分和混凝活性

丁香丁香的叶子和树皮用作民间药，具有清热，解毒，祛湿，黄疸的作用。由于其丰富的资源，对扁柏叶片的研究很多，但是关于扁柏花的组成成分的报道较少。先前对扁豆链球菌花的研究主要集中在挥发性成分及其传统药理活性上。因此，本研究旨在研究扁桃链球菌花的非挥发性化学成分和凝血活性。用各种色谱柱分离扁豆链球菌花的化学成分，并通过测定活化的部分凝血活酶时间（APTT），凝血酶原时间（PT），兔血浆中的凝血酶时间（TT）和纤维蛋白原（FIB）。从扁桃链球花中分离出十五种已知化合物（即化合物1-15）。化合物6、10、11和14首次从丁香属中分离出来。首次从植物中分离出化合物1、2、4、5、8和9。凝血活性的结果表明，与空白组相比，扁桃链球菌的水部分，月桂酸和山茱ol醇-芦丁糖显着缩短了PT（P <0.001），TT（P <0.001）和APTT（P <0.001），从而表明扁桃链球菌水提取物，月桂酸和山奈酚-芦丁糖具有促凝活性，但其效果并不优于云南白药作为阳性对照。化合物6、10、11和14首次从丁香属中分离出来。首次从植物中分离出化合物1、2、4、5、8和9。凝血活性的结果表明，与空白组相比，扁桃链球菌的水部分，月桂酸和山茱ol醇-芦丁糖显着缩短了PT（P <0.001），TT（P <0.001）和APTT（P <0.001），从而表明扁桃链球菌水提取物，月桂酸和山奈酚-芦丁糖具有促凝活性，但其效果并不优于云南白药作为阳性对照。化合物6、10、11和14首次从丁香属中分离出来。首次从植物中分离出化合物1、2、4、5、8和9。凝血活性的结果表明，与空白组相比，扁桃链球菌的水部分，月桂酸和山茱ol醇-芦丁糖显着缩短了PT（P <0.001），TT（P <0.001）和APTT（P <0.001），从而表明扁桃链球菌水提取物，月桂酸和山奈酚-芦丁糖具有促凝活性，但其效果并不优于云南白药作为阳性对照。