Myotonic dystrophy type 1 (DM1) is an inherited multi‐systemic disease involving the central nervous system (CNS) and is consequently characterized by a range of cognitive impairments. However, whether this cognitive profile progresses over time is still a matter of debate. The aim of this study was to longitudinally assess a DM1 sample, in order to compare, for the first time, this progression with that of a control group. Clinical and socio‐demographic predictive factors potentially implicated in this possible decline are analysed.

中文翻译：

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1型强直性肌营养不良症的年龄相关性认知功能下降：一项为期11年的纵向随访研究。

1型强直性肌营养不良症（DM1）是一种涉及中枢神经系统（CNS）的遗传性多系统疾病，因此具有一系列认知障碍的特征。然而，这种认知状况是否随着时间发展仍然是一个争论的问题。这项研究的目的是纵向评估DM1样本，以便首次将此进展与对照组进行比较。分析可能与这种可能下降有关的临床和社会人口统计学预测因素。