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First report of a successful pediatric heart transplantation from donation after circulatory death with distant procurement using normothermic regional perfusion and cold storage.
The Journal of Heart and Lung Transplantation ( IF 8.9 ) Pub Date : 2019-08-10 , DOI: 10.1016/j.healun.2019.08.009
Vincent Tchana-Sato 1 , Didier Ledoux 2 , Katrien Vandendriessche 3 , Johan Van Cleemput 4 , Gregory Hans 2 , Arnaud Ancion 5 , Bjorn Cools 4 , Philippe Amabili 2 , Olivier Detry 6 , Paul Bernard Massion 2 , Josee Monard 6 , Marie-Hélène Delbouille 6 , Bart Meyns 3 , Jean Olivier Defraigne 1 , Filip Rega 3
Affiliation  

Heart transplantation (HT) from donation after circulatory death (DCD) is a promising alternative to expand the heart donor pool. Cold storage can be used in a strategy to successfully retrieve and transplant DCD hearts after reconditioning using normothermic regional perfusion for distant procurement. Herein, we present the first report of a pediatric DCD heart reconditioned with normothermic regional perfusion, preserved using only cold storage while being transported to a neighboring center, and then successfully transplanted after nearly 2 hours of cold static storage. If supported by an appropriate trial, this finding could obviate the need to use expensive perfusion devices for short interhospital distances for DCD heart transportation and stimulate more centers across the world to embrace DCD HT.



中文翻译:

首次报告的小儿心脏移植成功是由于循环死亡后的捐赠,并使用正常体温区域灌注和冷库进行了远距离采购。

循环死亡(DCD)后捐献的心脏移植(HT)是扩大心脏供体库的有希望的替代方法。冷藏可用于策略后,使用正常体温区域灌注进行远距离采购,从而成功地恢复和移植DCD心脏。在此,我们提出了小儿DCD心脏的首次报道,该小儿DCD心脏经过正常体温区域灌注修复,仅在冷藏时被保存,同时被运送到附近的中心,然后在将近2小时的静态静态冷藏后成功移植。如果得到适当试验的支持,则该发现可以避免在院际距离短时使用昂贵的灌注设备进行DCD心脏运输的需求,并刺激全世界更多的中心接受DCD HT。

更新日期:2019-08-10
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