PURPOSE To perform in vitro assessments of surface haze and roughness, subsurface nanoglistenings (SSNGs), and glistenings of a new hydrophobic acrylic intraocular lens (IOL) in comparison to commercially available IOLs. SETTING Universities of Utah and Alcalá, and Alcon Vision, LLC. DESIGN Experimental study. METHODS The IOLs used were Clareon CNA0T0, Tecnis ZCB00 and Tecnis OptiBlue ZCB00V, Eternity W-60, enVista MX60, and Vivinex XY1. Surface haze was assessed by the pixel intensity units (PIU) from cross-sectional slitlamp images, and it was correlated to atomic force microscopy roughness. For SSNGs, the IOLs were artificially aged up to 10 years, followed by Scheimpflug densitometry (computer-compatible tape unit [CCTU]) measurements. For glistenings, the IOLs were immersed in a water bath and subjected to temperature changes before analysis. RESULTS The surface haze (n = 10, PIU) was 4.25 ± 0.87 (SD) (CNA0T0), 9.50 ± 1.66 (ZCB00), 39.48 ± 1.97 (ZCB00V), 46.68 ± 3.16 (W-60), 44.70 ± 4.00 (MX60), and 4.42 ± 0.71 (XY1) (P < .001), which showed a strong correlation with surface roughness measurements (R = 0.94, P = .006). The densitometry (n = 10, CCTU at 10 years) was 7.30 ± 1.36 (CNA0T0), 11.88 ± 3.10 (ZCB00), 38.12 ± 2.24 (ZCB00V), 48.13 ± 9.44 (W-60), 20.20 ± 3.84 (MX60), and 6.75 ± 6.66 (XY1) (P < .001), with no significant differences between CNA0T0 vs. ZCB00 and XY1. The glistenings density (n = 30) was the lowest for the CNA0T0, W-60, and MX60 IOLs. CONCLUSIONS The new Clareon CNA0T0, which is manufactured from a hydrophobic acrylic material, exhibited among the lowest levels of surface haze and roughness, SSNGs, and glistenings compared with other commercially available hydrophobic acrylic IOLs.

中文翻译：

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与市售IOL相比，新型疏水丙烯酸IOL的透明性评估。

目的与新的疏水性丙烯酸人工晶状体（IOL）相比，对新的疏水性丙烯酸人工晶状体（IOL）的表面雾度和粗糙度，亚表面纳米光泽（SSNG）和光泽进行体外评估。设置犹他州和阿尔卡拉大学，以及爱尔康视觉有限责任公司。设计实验研究。方法使用的IOL是Clareon CNA0T0，Tecnis ZCB00和Tecnis OptiBlue ZCB00V，Eternity W-60，enVista MX60和Vivinex XY1。表面雾度通过横截面裂隙灯图像的像素强度单位（PIU）进行评估，并且与原子力显微镜的粗糙度相关。对于SSNG，人工将IOL老化10年，然后进行Scheimpflug密度测量（计算机兼容磁带机[CCTU]）测量。为了闪闪发光 将IOL浸入水浴中，并在分析之前进行温度变化。结果表面雾度（n = 10，PIU）为4.25±0.87（SD）（CNA0T0），9.50±1.66（ZCB00），39.48±1.97（ZCB00V），46.68±3.16（W-60），44.70±4.00（MX60） ）和4.42±0.71（XY1）（P <.001），与表面粗糙度测量值显示出很强的相关性（R = 0.94，P = .006）。密度计（n = 10，10年时的CCTU）为7.30±1.36（CNA0T0），11.88±3.10（ZCB00），38.12±2.24（ZCB00V），48.13±9.44（W-60），20.20±3.84（MX60），和6.75±6.66（XY1）（P <.001），CNA0T0与ZCB00和XY1之间无显着差异。对于CNA0T0，W-60和MX60 IOL，闪耀密度（n = 30）最低。结论新型Clareon CNA0T0由疏水性丙烯酸材料制成，