A database on mechanistic characteristics of human carcinogenic agents was developed by collecting mechanistic information on agents identified as human carcinogens (Group 1) by the International Agency for Research on Cancer (IARC) in the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A two-phase process is described for the construction of the database according to 24 toxicological endpoints, derived from appropriate test systems that were acquired from data obtained from the mechanisms sections of the IARC Monographs (Section 4) and a supplementary PubMed search. These endpoints were then aligned with 10 key characteristics of human carcinogens that reflect the broader attributes of these agents relating to the development of cancer in humans. The considerations involved in linking of toxicological endpoints to key characteristics are described and specific examples of the determination of key characteristics for six specific agents (tamoxifen, hepatitis B virus, arsenic, ultraviolet and solar radiation, tobacco smoking, and dioxin) are provided. Data for humans and animals were tabulated separately, as were results for in-vivo and for in-vitro sources of information. The database was constructed to support a separate analysis of the expression of these endpoints by 86 Group 1 carcinogens, in-vivo and in-vitro along with an analysis of the key characteristics of these agents.

中文翻译：

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开发有关人类致癌物关键特征的数据库。

通过收集国际癌症研究机构（IARC）在IARC关于人类致癌风险评估的专着中确定为人类致癌物的药物信息（第1组），开发了有关人类致癌物力学特征的数据库。根据24个毒理学终点，描述了一个分两个阶段的数据库构建过程，这些终点是从适当的测试系统中获得的，这些测试系统是从IARC专论的机理部分（第4节）和补充的PubMed搜索中获得的数据而获得的。然后将这些终点与人类致癌物的10个关键特征对齐，这些特征反映了这些药物与人类癌症的发展有关的更广泛的属性。描述了将毒理学终点与关键特征联系起来的考虑因素，并提供了确定六种特定药物（他莫昔芬，乙型肝炎病毒，砷，紫外线和太阳辐射，吸烟和二恶英）的关键特征的具体示例。人和动物的数据分别制成表格，体内和体外信息来源的结果也被制成表格。构建该数据库以支持86种第1组致癌物在体内和体外对这些终点表达的单独分析，以及对这些药物关键特性的分析。和二恶英）。人和动物的数据分别制成表格，体内和体外信息来源的结果也被制成表格。构建该数据库以支持86种第1组致癌物在体内和体外对这些终点表达的单独分析，以及对这些药物关键特性的分析。和二恶英）。人和动物的数据分别制成表格，体内和体外信息来源的结果也被制成表格。构建该数据库以支持86种第1组致癌物在体内和体外对这些终点表达的单独分析，以及对这些药物关键特性的分析。