Recently Koronowski et al. (Cell, 2019) showed that reconstitution of the liver circadian clock in otherwise genetically arrhythmic mice revives the daily program of the nicotinamide adenine dinucleotide salvage pathway and glycogenesis in vivo. This liver-autonomous metabolic cycling cannot be sustained under constant darkness, revealing the importance of the daily light cycle to restore liver function.

中文翻译：

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机体肝脏时钟功能的重建需要光

最近 Koronowski 等人。(Cell, 2019) 表明，在其他遗传性心律失常小鼠中重建肝脏生物钟可以恢复体内烟酰胺腺嘌呤二核苷酸补救途径和糖生成的日常程序。这种肝脏自主代谢循环在持续的黑暗中无法持续，揭示了每日光照循环对恢复肝功能的重要性。