It is now rare to find biological, or genetic investigations that do not rely on the tools, data, and thinking drawn from the genomic sciences. Much of this revolution is powered by contemporary sequencing approaches that readily deliver large, genome-wide data sets that not only provide genetic insights but also uniquely report molecular outcomes from experiments that biophysicists are increasingly using for potentiating structural and mechanistic investigations. In this perspective, I describe a path of how biophysical thinking greatly contributed to this revolution in ways that parallel advancements in computer science through discussion of several key inventions, described as "foundational devices." These discussions also point at the future of how biophysics and the genomic sciences may become more finely integrated for empowering new measurement paradigms for biological investigations.

中文翻译：

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生物物理学和基因组科学

现在很少能找到不依赖于从基因组科学中提取的工具、数据和思维的生物学或基因研究。这场革命的很大一部分是由当代测序方法提供动力的，这些方法可以轻松提供大型的全基因组数据集，这些数据集不仅提供遗传洞察力，而且还独特地报告了生物物理学家越来越多地用于加强结构和机制研究的实验的分子结果。从这个角度来看，我通过讨论几个被称为“基础设备”的关键发明，描述了生物物理思维如何以并行计算机科学进步的方式对这场革命做出巨大贡献的路径。