Telomere and telomerase play important roles in abnormal cell proliferation, metastasis, stem cell maintenance, and immortalization in various cancers. Therefore, designing of drugs targeting telomerase and telomere is of great significance. Over the past two decades, considerable knowledge regarding telomere and telomerase has been accumulated, which provides theoretical support for the design of therapeutic strategies such as telomere elongation. Therefore, the development of telomere‐based therapies such as nucleoside analogs, non‐nucleoside small molecules, antisense technology, ribozymes, and dominant negative human telomerase reverse transcriptase are being prioritized for eradicating a majority of tumors. While the benefits of telomere‐based therapies are obvious, there is a need to address the limitations of various therapeutic strategies to improve the possibility of clinical applications. In this study, current knowledge of telomere and telomerase is discussed, and therapeutic strategies based on recent research are reviewed.

中文翻译：

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在癌症中靶向端粒酶的治疗策略。

端粒和端粒酶在各种癌症的异常细胞增殖，转移，干细胞维持和永生化中起重要作用。因此，设计靶向端粒酶和端粒的药物具有重要意义。在过去的二十年中，已经积累了有关端粒和端粒酶的大量知识，为端粒延长等治疗策略的设计提供了理论支持。因此，目前优先考虑开发端粒疗法，如核苷类似物，非核苷小分子，反义技术，核酶和人类端粒酶阴性的主要逆转录酶，以根除大多数肿瘤。尽管端粒疗法的好处显而易见，需要解决各种治疗策略的局限性以提高临床应用的可能性。在这项研究中，讨论了端粒和端粒酶的当前知识，并综述了基于最近研究的治疗策略。