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Formate metabolism in health and disease.
Molecular Metabolism ( IF 8.1 ) Pub Date : 2019-07-30 , DOI: 10.1016/j.molmet.2019.05.012
Matthias Pietzke 1 , Johannes Meiser 2 , Alexei Vazquez 3
Affiliation  

Background

Formate is a one-carbon molecule at the crossroad between cellular and whole body metabolism, between host and microbiome metabolism, and between nutrition and toxicology. This centrality confers formate with a key role in human physiology and disease that is currently unappreciated.

Scope of review

Here we review the scientific literature on formate metabolism, highlighting cellular pathways, whole body metabolism, and interactions with the diet and the gut microbiome. We will discuss the relevance of formate metabolism in the context of embryonic development, cancer, obesity, immunometabolism, and neurodegeneration.

Major conclusions

We will conclude with an outlook of some open questions bringing formate metabolism into the spotlight.



中文翻译:

在健康和疾病中形成新陈代谢。

背景

甲酸酯是一种碳原子分子,处于细胞与全身代谢,宿主与微生物组代谢以及营养与毒理学之间的十字路口。这种中心性赋予了人类在目前尚不了解的生理和疾病中的关键作用。

审查范围

在这里,我们回顾关于甲酸盐代谢的科学文献,重点介绍细胞途径,全身代谢以及与饮食和肠道微生物组的相互作用。我们将讨论在胚胎发育,癌症,肥胖,免疫代谢和神经退行性疾病中甲酸代谢的相关性。

主要结论

我们将以使甲酸代谢成为人们关注的一些悬而未决的问题作为结束。

更新日期:2019-07-30
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