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Macrophages at CNS interfaces: ontogeny and function in health and disease.
Nature Reviews Neuroscience ( IF 34.7 ) Pub Date : 2019-07-29 , DOI: 10.1038/s41583-019-0201-x
Katrin Kierdorf 1, 2, 3 , Takahiro Masuda 1 , Marta Joana Costa Jordão 1 , Marco Prinz 1, 2, 3, 4
Affiliation  

The segregation and limited regenerative capacity of the CNS necessitate a specialized and tightly regulated resident immune system that continuously guards the CNS against invading pathogens and injury. Immunity in the CNS has generally been attributed to neuron-associated microglia in the parenchyma, whose origin and functions have recently been elucidated. However, there are several other specialized macrophage populations at the CNS borders, including dural, leptomeningeal, perivascular and choroid plexus macrophages (collectively known as CNS-associated macrophages (CAMs)), whose origins and roles in health and disease have remained largely uncharted. CAMs are thought to be involved in regulating the fine balance between the proper segregation of the CNS, on the one hand, and the essential exchange between the CNS parenchyma and the periphery, on the other. Recent studies that have been empowered by major technological advances have shed new light on these cells and suggest central roles for CAMs in CNS physiology and in the pathogenesis of diseases.

中文翻译:

中枢神经系统界面处的巨噬细胞:个体发育和健康和疾病中的功能。

中枢神经系统的分离和有限的再生能力需要一个专门且严格调节的常驻免疫系统,以持续保护中枢神经系统免受入侵病原体和伤害。中枢神经系统中的免疫通常归因于实质中与神经元相关的小胶质细胞,其起源和功能最近已被阐明。然而,在中枢神经系统边界还有其他几个特殊的巨噬细胞群,包括硬脑膜、软脑膜、血管周围和脉络丛巨噬细胞(统称为中枢神经系统相关巨噬细胞 (CAM)),它们的起源和在健康和疾病中的作用在很大程度上仍然未知。CAM 被认为参与调节中枢神经系统的适当分离之间的精细平衡,一方面,中枢神经系统实质与外围之间的基本交换,在另一。受重大技术进步支持的最新研究为这些细胞提供了新的视角,并提出了 CAM 在 CNS 生理学和疾病发病机制中的核心作用。
更新日期:2019-11-18
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