Ribosomal RNA (rRNA) is co- and post-transcriptionally processed into active ribosomes. This process is dynamically regulated by direct covalent modifications of the polymerase that synthesizes the rRNA, RNA polymerase I (Pol I), and by interactions with cofactors that influence initiation, elongation, and termination activities of Pol I. The rate of transcription elongation by Pol I directly influences processing of nascent rRNA, and changes in Pol I transcription rate result in alternative rRNA processing events that lead to cellular signaling alterations and stress. It is clear that in divergent species, there exists robust organization of nascent rRNA processing events during transcription elongation. This review evaluates the current state of our understanding of the complex relationship between transcription elongation and rRNA processing.

中文翻译：

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RNA聚合酶I对rRNA加工的协调控制。

核糖体 RNA (rRNA) 被共同转录和转录后加工成活性核糖体。该过程通过合成 rRNA、RNA 聚合酶 I (Pol I) 的聚合酶的直接共价修饰以及与影响 Pol I 起始、延伸和终止活性的辅因子的相互作用进行动态调节。 Pol 的转录延伸率I 直接影响新生 rRNA 的加工，Pol I 转录率的变化导致替代 rRNA 加工事件，从而导致细胞信号传导改变和压力。很明显，在不同的物种中，在转录延伸过程中，新生的 rRNA 加工事件存在强大的组织。本综述评估了我们对转录延伸和 rRNA 加工之间复杂关系的理解的现状。