Mitochondria, the double membrane-walled powerhouses of the eukaryotic cell, are also the seats of synthesis of two critical yet prevalent nonbilayer-prone phospholipids, namely phosphatidylethanolamine (PE) and cardiolipin (CL). Besides their established biochemical roles in the regulation of partner protein function, PE and CL are also key protagonists in the biophysics of mitochondrial membrane remodeling and dynamics. In this review, we address lipid geometry and behavior at the single-molecule level as well as their intimate coupling to whole organelle morphology and remodeling during the concerted events of mitochondrial fission. We present evidence from recent experimental measurements ably supported and validated by computational modeling studies to support our notion that conical lipids play a catalytic as well as a structural role in mitochondrial fission.

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探索脂质几何与线粒体裂变之间的联系：新兴概念

线粒体是真核细胞的双膜壁动力源，也是两种关键但普遍存在的非双层磷脂，即磷脂酰乙醇胺 (PE) 和心磷脂 (CL) 的合成场所。除了它们在调节伴侣蛋白功能方面的既定生化作用外，PE 和 CL 也是线粒体膜重塑和动力学生物物理学的关键主角。在这篇综述中，我们讨论了单分子水平的脂质几何结构和行为，以及它们与整个细胞器形态的密切耦合，以及在线粒体裂变的协同事件中的重塑。