Trends in Molecular Medicine ( IF 13.6 ) Pub Date : 2019-07-25 , DOI: 10.1016/j.molmed.2019.06.007 Jian Chen 1 , Julian A Gingold 2 , Xiaoping Su 3
Hepatocellular carcinoma (HCC) is an inflammation-induced and chemotherapy-resistant cancer. Dysregulated signaling in the transforming growth factor beta (TGF-β) pathway plays a central role in inflammation, fibrogenesis, and immunomodulation in the HCC microenvironment. This review dissects the genetic landscape of the TGF-β superfamily genes in HCC and discusses the essential effects of this pathway on the tumor immune microenvironment. We highlight the TGF-β signature as a potential biomarker for identifying individualized immunotherapeutic approaches in HCC. An improved understanding of the detailed mechanisms of liver cancer immunogenicity and the specific role of TGF-β in mediating immunotherapy resistance in HCC will provide important insights into HCC immune escape and promote the development of biomarker-derived combination immunotherapies for HCC.
中文翻译:
肝细胞癌中的免疫调节性TGF-β信号传导。
肝细胞癌(HCC)是一种炎症诱导和化疗耐药的癌症。转化生长因子β(TGF-β)途径中信号传导失调在HCC微环境中的炎症,纤维生成和免疫调节中起着核心作用。本文综述了肝癌中TGF-β超家族基因的遗传结构,并讨论了该途径对肿瘤免疫微环境的重要作用。我们着重介绍了TGF-β标记物作为一种潜在的生物标志物,可用于鉴定HCC中的个性化免疫治疗方法。