Published as part of the Special Topic Alkali base mediated coupling reactions without added transition metal

Abstract

The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.

The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.

中文翻译：

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氢化钠-碘化锂复合物在亲核芳香胺化反应中的离去基团能力

在不添加过渡金属的情况下作为特殊主题碱碱介导的偶联反应的一部分发布

抽象的

甲氧基通常被认为是亲核取代反应的弱离去基团。这项工作通过实验和计算方法验证了氢化钠和碘化锂介导的芳烃亲核胺化中甲氧基的优越能力。

甲氧基通常被认为是亲核取代反应的弱离去基团。这项工作通过实验和计算方法验证了氢化钠和碘化锂介导的芳烃亲核胺化中甲氧基的优越能力。