The potential impact of TiO₂ and Fe incorporated TiO₂ nanoparticles at the organelle level has been reported. The toxicity of the samples on mitochondria isolated from chicken liver tissue has been examined through mitochondrial swelling, membrane fluidity, ROS generation capacity, and activity of complex II. The toxic effect of TiO₂ was prevented by incorporating Fe into the TiO₂ matrix at different concentrations. The activity of the succinate dehydrogenase enzyme complex was affected and permeabilization of the mitochondrial inner membrane to H⁺ and K⁺ and its alteration in membrane fluidity at 100 μg mL⁻¹ of nano-TiO₂ dosage were investigated, which showed significant changes in the anisotropy of DPH-labeled mitochondria. Fe incorporation into the TiO₂ matrix makes it more biocompatible by changing its structure and morphology.

中文翻译：

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研究纳米 TiO2 诱导并通过 Fe 掺入阻止线粒体肿胀、膜流动性和 ROS 产生。

_{TiO 2}和Fe掺入的TiO ₂纳米颗粒在细胞器水平上的潜在影响已有报道。通过线粒体肿胀、膜流动性、ROS 生成能力和复合物 II 的活性检查了样品对从鸡肝组织中分离的线粒体的毒性。通过将不同浓度的Fe掺入TiO _{2基质中，可以防止TiO 2}的毒性作用。琥珀酸脱氢酶复合物的活性受到影响，并研究了纳米TiO _{2剂量为100 μg mL} ^-1时线粒体内膜对H ⁺和K ⁺的通透性及其膜流动性的变化，结果表明， DPH 标记线粒体的各向异性。Fe 掺入 TiO ₂基质中，通过改变其结构和形态使其更具生物相容性。