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Circadian and Circannual Timescales Interact to Generate Seasonal Changes in Immune Function
Brain, Behavior, and Immunity ( IF 15.1 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.bbi.2019.07.024
Kenneth G Onishi 1 , Andrew C Maneval 1 , Erin C Cable 1 , Mary Claire Tuohy 1 , Andrew J Scasny 1 , Evelina Sterina 1 , Jharnae A Love 1 , Jonathan P Riggle 1 , Leah K Malamut 1 , Aashna Mukerji 1 , Jennifer S Novo 1 , Abena Appah-Sampong 1 , Joseph B Gary 1 , Brian J Prendergast 2
Affiliation  

Annual changes in day length enhance or suppress diverse aspects of immune function, giving rise to seasonal cycles of illness and mortality. The daily light-dark cycle also entrains circadian rhythms in immunity. Most published reports on immunological seasonality rely on measurements or interventions performed only at one point in the day. Because there can be no perfect matching of circadian phase across photoperiods of different duration, the manner in which these timescales interact to affect immunity is not understood. We examined whether photoperiodic changes in immune function reflect phenotypic changes that persist throughout the circadian cycle, or merely reflect photoperiodic shifts in the circadian alignment of immunological rhythms. Circadian rhythms in blood leukocyte trafficking, infection induced sickness responses, and delayed-type hypersensitivity skin inflammatory responses were examined at high-frequency sampling intervals (every 3 h) in Siberian hamsters (Phodopus sungorus) following immunological adaptation to summer or winter photoperiods. Photoperiod profoundly enhanced or suppressed immune function, in a trait-specific manner, and we were unable to identify a phase alignment of circadian waveforms which eliminated these enhancing and suppressing effects of photoperiod. The results support the hypothesis that seasonal timescales affect immunity via mechanisms independent of circadian entrainment of the immunological circadian waveform.

中文翻译:

昼夜节律和周年时间尺度相互作用以产生免疫功能的季节性变化

昼长的年度变化会增强或抑制免疫功能的各个方面,从而导致疾病和死亡率的季节性循环。每天的明暗循环也会影响免疫的昼夜节律。大多数已发表的关于免疫季节性的报告依赖于仅在一天中的一个时间点进行的测量或干预。因为在不同持续时间的光周期中不可能有完美的昼夜节律相匹配,所以这些时间尺度相互作用以影响免疫的方式尚不清楚。我们检查了免疫功能的光周期变化是否反映了在整个昼夜节律周期中持续存在的表型变化,或者仅反映了免疫节律的昼夜节律排列中的光周期变化。血液白细胞运输的昼夜节律,感染引起的疾病反应,在对夏季或冬季光周期的免疫适应之后,在西伯利亚仓鼠 (Phodopus sungorus) 中以高频采样间隔(每 3 小时)检查和延迟型超敏性皮肤炎症反应。光周期以性状特异性方式显着增强或抑制免疫功能,我们无法确定消除了光周期的这些增强和抑制作用的昼夜节律波形的相位对齐。结果支持季节性时间尺度通过独立于免疫昼夜节律波形的昼夜节律夹带的机制影响免疫的假设。光周期以性状特异性方式显着增强或抑制免疫功能,我们无法确定消除了光周期的这些增强和抑制作用的昼夜节律波形的相位对齐。结果支持季节性时间尺度通过独立于免疫昼夜节律波形的昼夜节律夹带的机制影响免疫的假设。光周期以性状特异性方式显着增强或抑制免疫功能,我们无法确定消除了光周期的这些增强和抑制作用的昼夜节律波形的相位对齐。结果支持季节性时间尺度通过独立于免疫昼夜节律波形的昼夜节律夹带的机制影响免疫的假设。
更新日期:2020-01-01
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