Cellular senescence is a major driver of age-related diseases, and senotherapies are being tested in clinical trials. Despite its popularity, cellular senescence is weakly defined and is frequently referred to as irreversible cell-cycle arrest. In this article we hypothesize that cellular senescence is a phenotype that results from the coordination of two processes: cell expansion and cell-cycle arrest. We provide evidence for the compatibility of the proposed model with recent findings showing senescence in postmitotic tissues, wound healing, obesity, and development. We believe our model also explains why some characteristics of senescence can be found in non-senescent cells. Finally, we propose new avenues for research from our model.

中文翻译：

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扩张和细胞周期阻滞：细胞衰老的共同分母。

细胞衰老是与年龄有关的疾病的主要驱动力，并且在临床试验中正在对衰老疗法进行测试。尽管很受欢迎，但细胞衰老的定义很微弱，通常被称为不可逆的细胞周期停滞。在本文中，我们假设细胞衰老是一种表型，由两个过程的协调产生：细胞扩增和细胞周期停滞。我们为拟议的模型与最近的发现表明有丝分裂后组织中的衰老，伤口愈合，肥胖和发育的兼容性提供了证据。我们相信我们的模型还可以解释为什么可以在非衰老细胞中发现某些衰老特征。最后，我们从模型中提出了新的研究途径。