BACKGROUND Surgical site infections (SSIs) are associated with morbidity, mortality and costs. AIM To identify the burden of (deep) SSIs in costs and disability-adjusted life years (DALYs) following colectomy, mastectomy and total hip arthroplasty (THA) in the Netherlands. METHODS A retrospective cost-analysis was performed using 2011 data from the national SSI surveillance network PREZIES. Sixty-two patients with an SSI (exposed) were matched to 122 patients without an SSI (unexposed, same type of surgery). Patient records were studied until 1 year after SSI diagnosis. Unexposed patients were followed for the same duration. Costs were calculated from the hospital perspective (2016 price level), and cost differences were tested using linear regression analyses. Disease burden was estimated using the Burden of Communicable Disease in Europe Toolkit of the European Centre for Disease Prevention and Control. The SSI model was specified by type of surgery, with country- and surgery-specific parameters where possible. FINDINGS Attributable costs per SSI were €21,569 (THA), €14,084 (colectomy) and €1881 (mastectomy), mainly caused by prolonged length of hospital stay. National hospital costs were estimated at €10 million, €29 million and €0.6 million, respectively. National disease burden was greatest for SSIs following colectomy (3200 DALYs/year, 150 DALYs/100 SSIs), while individual disease burden was highest following THA (1200 DALYs/year, 250 DALYs/100 SSIs). For mastectomy, these DALYs were <1. The total cost of DALYs for the three types of surgery exceeded €88 million. CONCLUSION Depending on the type of surgery, SSIs cause a significant burden, both economically and in loss of years in full health. This underlines the importance of appropriate infection prevention and control measures.

中文翻译：

---

荷兰外科手术部位感染的负担：成本分析和残障调整生命年。

背景技术手术部位感染（SSI）与发病率，死亡率和成本有关。目的确定在荷兰进行结肠切除术，乳房切除术和全髋关节置换术（THA）后，（深度）SSI在成本和残疾调整生命年（DALY）中的负担。方法使用来自国家SSI监视网络PREZIES的2011年数据进行回顾性成本分析。将62例SSI（暴露）的患者与122例没有SSI（未暴露，相同类型的手术）的患者相匹配。对患者记录进行研究，直到SSI诊断后1年。未接触患者的随访时间相同。从医院角度（2016年价格水平）计算成本，并使用线性回归分析测试成本差异。使用欧洲疾病预防和控制中心的欧洲传染病负担工具包估计疾病负担。根据手术类型指定SSI模型，并在可能的情况下使用特定国家/地区和特定于手术的参数。结果每个SSI的可归属费用分别为21,569欧元（THA），14,084欧元（结肠切除术）和1881欧元（乳房切除术），主要是由于住院时间延长所致。国家医院的费用估计分别为1000万欧元，2900万欧元和60万欧元。结肠切除术后的SSI的国家疾病负担最大（3200 DALYs /年，150 DALYs / 100 SSI），而个体疾病负担最高的是THA（1200 DALYs /年，250 DALYs / 100 SSI）。对于乳房切除术，这些DALY小于1。这三种手术的DALY的总费用超过8800万欧元。结论根据手术类型的不同，SSI会造成巨大的负担，无论是经济上的损失还是完全健康所造成的损失。这强调了适当的感染预防和控制措施的重要性。