Biological information can be shared between cells via extracellular vesicles. However, how cargo carried by extracellular vesicles elicits biological responses remains unresolved. Deciphering the molecular mechanisms that govern packaging and targeted delivery of extracellular vesicle cargo will be required to establish extracellular vesicles as important signalling entities. Stahl and Raposo discuss the emerging paradigm of cell–cell signalling via extracellular vesicles, highlighting key questions that need to be answered to firmly establish extracellular vesicles as important signalling entities.

中文翻译：

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细胞外囊泡：一种新的交流范式？

可以通过细胞外小泡在细胞之间共享生物学信息。然而，细胞外囊泡所载货物如何引起生物学反应仍未解决。需要破译控制细胞外小泡货物包装和靶向递送的分子机制，以将细胞外小泡建立为重要的信号传导实体。Stahl和Raposo讨论了通过细胞外小泡形成的细胞间信号传导的新兴范式，强调了必须回答的关键问题，才能牢固地将细胞外小泡确立为重要的信号传导实体。