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Ultrasonically sculpted virtual relay lens for in situ microimaging
Light: Science & Applications ( IF 19.4 ) Pub Date : 2019-07-17 , DOI: 10.1038/s41377-019-0173-7
Matteo Giuseppe Scopelliti , Maysamreza Chamanzar

We demonstrate in situ non-invasive relay imaging through a medium without inserting physical optical components. We show that a virtual optical graded-index (GRIN) lens can be sculpted in the medium using in situ reconfigurable ultrasonic interference patterns to relay images through the medium. Ultrasonic wave patterns change the local density of the medium to sculpt a graded refractive index pattern normal to the direction of light propagation, which modulates the phase front of light, causing it to focus within the medium and effectively creating a virtual relay lens. We demonstrate the in situ relay imaging and resolving of small features (22 µm) through a turbid medium (optical thickness = 5.7 times the scattering mean free path), which is normally opaque. The focal distance and the numerical aperture of the sculpted optical GRIN lens can be tuned by changing the ultrasonic wave parameters. As an example, we experimentally demonstrate that the axial focal distance can be continuously scanned over a depth of 5.4 mm in the modulated medium and that the numerical aperture can be tuned up to 21.5%. The interaction of ultrasonic waves and light can be mediated through different physical media, including turbid media, such as biological tissue, in which the ultrasonically sculpted GRIN lens can be used for relaying images of the underlying structures through the turbid medium, thus providing a potential alternative to implanting invasive endoscopes.



中文翻译:

超声雕刻的虚拟中继透镜,用于原位微成像

我们演示了通过介质的原位非侵入性中继成像,而无需插入物理光学组件。我们显示,可以使用原位可重新配置的超声干涉图样通过介质在虚拟介质中雕刻虚拟光学渐变折射率(GRIN)透镜。超声波图案会改变介质的局部密度,以雕刻垂直于光传播方向的渐变折射率图案,从而调制光的相位前缘,使其聚焦在介质中并有效地创建虚拟中继透镜。我们演示了通过浑浊的介质(光学厚度= 5.7倍的散射平均自由程)进行原位中继成像和分辨小特征(22 µm)的过程,该介质通常是不透明的。可以通过更改超声波参数来调整雕刻的光学GRIN透镜的焦距和数值孔径。例如,我们实验证明轴向焦距可以在调制介质中的5.4 mm深度上连续扫描,并且数值孔径可以调整到21.5%。超声波和光的相互作用可以通过不同的物理介质进行介导,包括诸如生物组织之类的混浊介质,其中超声雕刻的GRIN透镜可用于通过混浊介质中继下层结构的图像,从而提供了一种潜在的可能性。替代植入式侵入性内窥镜。我们通过实验证明轴向焦距可以在调制介质中的5.4 mm深度上连续扫描,并且数值孔径可以调整到21.5%。超声波和光的相互作用可以通过不同的物理介质进行介导,包括诸如生物组织之类的混浊介质,其中超声雕刻的GRIN透镜可用于通过混浊介质中继下层结构的图像,从而提供了一种潜在的可能性。替代植入式侵入性内窥镜。我们通过实验证明轴向焦距可以在调制介质中的5.4 mm深度上连续扫描,并且数值孔径可以调整到21.5%。超声波和光的相互作用可以通过不同的物理介质进行介导,包括诸如生物组织之类的混浊介质,其中超声雕刻的GRIN透镜可用于通过混浊介质中继下层结构的图像,从而提供了一种潜在的潜力。替代植入式侵入性内窥镜。

更新日期:2019-11-18
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