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Towards Quality by Design and process analytical technology for enhanced nutrient recovery from wastewaters
npj Clean Water ( IF 11.4 ) Pub Date : 2019-07-15 , DOI: 10.1038/s41545-019-0038-x
Céline Vaneeckhaute

Recovering nutrients from wastewater as sustainable bio-based products provides a key solution to major environmental problems. Classical technology development approaches for resource recovery largely ignore the real-world variability in raw waste materials, which currently hinders the successful implementation of recovery strategies. A major challenge is to create a consistent and environmentally friendly supply of high-quality end-products that can compete with fossil-derived products currently on the market. This paper suggests the use of a Quality by Design approach as adapted from the pharmaceutical industry to ensure a high standard of quality consistency. Key elements of this approach involve mathematical models and integrated design-control strategies that support the production of high-quality marketable end-products from variable input waste and wastewater streams. Further research in terms of cost evaluation and optimisation of such approach for resource recovery applications is needed. A regulatory framework for Process Analytical Technology implementation in the field is also suggested.



中文翻译:

通过设计和过程分析技术提高质量,以提高废水中的养分回收率

作为可持续的生物基产品从废水中回收养分,为解决重大环境问题提供了关键解决方案。用于资源回收的经典技术开发方法在很大程度上忽略了原始废料的实际变化,这目前阻碍了回收策略的成功实施。一个主要的挑战是要创造一种始终如一,对环境友好的高质量最终产品供应,以与目前市场上的化石衍生产品竞争。本文建议使用从制药行业改编的“按质量设计”方法,以确保高标准的质量一致性。该方法的关键要素包括数学模型和集成的设计控制策略,以支持从可变输入废物和废水流中生产高质量的可销售最终产品。需要在成本评估和针对资源回收应用的这种方法的优化方面进行进一步研究。还建议在现场实施过程分析技术的监管框架。

更新日期:2019-07-15
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