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How does Pseudomonas aeruginosa affect the progression of bronchiectasis?
Clinical Microbiology and Infection ( IF 14.2 ) Pub Date : 2019-07-12 , DOI: 10.1016/j.cmi.2019.07.010
Y-H Chai 1 , J-F Xu 1
Affiliation  

BACKGROUND Pseudomonas aeruginosa is one of the most common pathogens isolated from respiratory tract specimen in patients with bronchiectasis. It is considered highly responsible for pathogenicity, progression and clinical outcomes of bronchiectasis. AIMS To summarize existing evidence on how different factors of Pseudomonas aeruginosa affect the pathogenicity, progression and clinical outcomes of bronchiectasis, so as to provide possible insights for clinical practice and related research in the future. SOURCES PubMed was searched for studies pertaining to bronchiectasis and P. aeruginosa published to date, with no specific inclusion or exclusion criteria. Reference lists of retrieved reviews were searched for additional articles. CONTENT This review focused on non-cystic fibrosis bronchiectasis and also provided some data on cystic fibrosis when studies in bronchiectasis were limited. We discussed various factors in relation to P. aeruginosa: virulence factors, drug resistance, regulatory systems, genomic diversity and transmission of P. aeruginosa, as well as treatment for P. aeruginosa. Their impacts on bronchiectasis and its management were discussed. IMPLICATIONS The impact of P. aeruginosa on bronchiectasis is definite, although conclusions in some aspects are still vague. Faced with the worrying drug-resistance status and treatment bottleneck, individualized management and novel therapies beyond the classic pathway are most likely to be a future trend. To confirm the independent or integrated impact of various factors of P. aeruginosa on bronchiectasis and to figure out all the problems mentioned, larger randomized control trials are truly needed in the future.

中文翻译:

铜绿假单胞菌如何影响支气管扩张?

背景技术铜绿假单胞菌是从支气管扩张患者的呼吸道标本中分离出的最常见的病原体之一。它被认为对支气管扩张的致病性,进展和临床结果负有高度责任。目的总结关于铜绿假单胞菌不同因素如何影响支气管扩张的致病性,进展和临床结果的现有证据,以便为将来的临床实践和相关研究提供可能的见解。来源检索PubMed,以查找与迄今发表的支气管扩张和铜绿假单胞菌有关的研究,没有明确的纳入或排除标准。在检索到的评论的参考列表中搜索其他文章。内容本综述着重于非囊性纤维化支气管扩张,并且当对支气管扩张的研究受到限制时,还提供了一些关于囊性纤维化的数据。我们讨论了与铜绿假单胞菌有关的各种因素:毒力因子,耐药性,调节系统,铜绿假单胞菌的基因组多样性和传播以及铜绿假单胞菌的治疗。讨论了它们对支气管扩张及其管理的影响。含铜绿假单胞菌对支气管扩张的影响是确定的,尽管在某些方面的结论仍含糊不清。面对令人担忧的耐药性和治疗瓶颈,超越经典途径的个性化管理和新疗法极有可能成为未来的趋势。确认P的各种因素的独立或综合影响。
更新日期:2020-02-21
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