Given the limitations of prescription antidepressants, many individuals have turned to natural remedies for the management of their mood disorders. We review three selected natural remedies that may be of potential use as treatments for depressive disorders and other psychiatric or neurological conditions. The best studied and best supported of these three remedies is S-adenosyl-L-methionine (SAMe), a methyl donor with a wide range of physiological functions in the human organism. With the increasing legalization of cannabis-related products, cannabidiol (CBD) has gained popularity for various potential indications and has even obtained approval in the United States and Canada for certain neurological conditions. Kratom, while potentially useful for certain individuals with psychiatric disorders, is perhaps the most controversial of the three remedies, in view of its greater potential for abuse and dependence. For each remedy, we will review indications, doses and delivery systems, potential anti-inflammatory and immunomodulatory action, adverse effects, and will provide recommendations for clinicians who may be considering prescribing these remedies in their practice.

中文翻译：

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S-腺苷-L-甲硫氨酸 (SAMe)、大麻二酚 (CBD) 和 Kratom 在精神疾病中的应用：临床和机制考虑

鉴于处方抗抑郁药的局限性，许多人已经转向自然疗法来管理他们的情绪障碍。我们回顾了三种选定的自然疗法，它们可能可用于治疗抑郁症和其他精神或神经系统疾病。在这三种疗法中，研究得最充分、支持最充分的是 S-腺苷-L-甲硫氨酸 (SAMe)，它是一种在人体有机体中具有广泛生理功能的甲基供体。随着大麻相关产品的日益合法化，大麻二酚 (CBD) 在各种潜在适应症中越来越受欢迎，甚至在美国和加拿大获得了某些神经系统疾病的批准。Kratom 虽然对某些患有精神疾病的人可能有用，鉴于其滥用和依赖的可能性更大，这可能是三种补救措施中最具争议的。对于每种药物，我们将审查适应症、剂量和给药系统、潜在的抗炎和免疫调节作用、不良反应，并将为可能考虑在实践中开出这些药物的临床医生提供建议。