West Nile virus (WNV) is transmitted by mosquitoes and can cause severe disease, including meningoencephalitis. AgBR1 is a mosquito salivary protein that enhances Aedes aegypti mosquito-borne Zika virus pathogenesis in mice. Here, we show that AgBR1 antibodies reduce the initial West Nile viral load and delay lethal infection after feeding by an infected Aedes aegypti mosquito. Targeting AgBR1 may therefore be incorporated into strategies to prevent mosquito-transmitted West Nile virus infection.

中文翻译：

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AgBR1抗体可延缓小鼠埃及伊蚊传播的致命西尼罗河病毒感染

西尼罗河病毒（WNV）是通过蚊子传播的，可导致包括脑膜脑炎在内的严重疾病。AgBR1是一种蚊唾液蛋白，可增强埃及伊蚊蚊子携带的寨卡病毒的发病机理。在这里，我们显示AgBR1抗体降低了最初的西尼罗河病毒载量，并延迟了被感染的埃及伊蚊（Aedes aegypti）蚊食后的致死性感染。因此，可以将靶向AgBR1纳入预防蚊子传播的西尼罗河病毒感染的策略。