Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore applications in other fields, and several examples that describe biomaterial blends in which ELRs have a key role. This review aims to give an overview of the recent advances regarding ELRs and to encourage further investigation of their properties and applications.

中文翻译：

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弹性蛋白样重组体作为生物材料的设计和使用趋势。

在过去的几年中，已从多个角度深入研究了源自天然弹性蛋白中重复域之一的类弹性蛋白重组蛋白（ELR）。在这个小型综述中，我们将讨论与ELR研究相关的所有最新工作，首先是将这些多肽定义为模型固有失调的蛋白质或区域（IDP或IDR）的文献，以及它们与某些生物医学应用的相关性。此外，我们总结了有关基于ELR的药物，疫苗和基因递送系统开发的当前知识，同时也强调了基于ELR的水凝胶在组织工程和再生医学（TERM）中的用途。最后，我们展示了探索其他领域应用的不同研究，以及描述了ELR在其中发挥关键作用的生物材料混合物的几个示例。