Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway (HBP). The HBP culminates in the production of an amino sugar uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) that, along with other charged nucleotide sugars, serves as the basis for biosynthesis of glycoproteins and other glycoconjugates. These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. In this review, we discuss recent progress in understanding the mechanistic relationship between the HBP and cancer.

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助燃：己糖胺生物合成途径在癌症中的新兴作用

如今，新陈代谢的改变和细胞能量的失控被认为是所有癌症的标志。葡萄糖，谷氨酰胺，脂肪酸和氨基酸是肿瘤生长的主要驱动力，并充当六胺生物合成途径（HBP）的底物。HBP最终产生了氨基糖尿苷二磷酸N-乙酰氨基葡萄糖（UDP-GlcNAc），它与其他带电荷的核苷酸糖一起，是糖蛋白和其他糖缀合物生物合成的基础。这些营养驱动的翻译后修饰在癌症中发生了很大的变化，并在各种与癌症相关的过程中调节蛋白质的功能。在这篇综述中，我们讨论了了解HBP与癌症之间的机械关系的最新进展。