Background

Allergic disease is the most frequent chronic health issue in children and has been linked to early-life gut microbiome dysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance.

Objective

We sought to determine whether bacterial butyrate production in the gut during early infancy is protective against the development of atopic disease in children.

Methods

We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in human infants, before their developing allergic disease.

Results

We found that the microbiome of infants who went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production.

Conclusions

Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against the development of allergies.

中文翻译：

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发生过敏致敏的婴儿肠道微生物组中丁酸发酵的遗传潜力降低。

背景

过敏性疾病是儿童中最常见的慢性健康问题，并且与早期肠道微生物组营养不良有关。许多证据表明，微生物衍生的短链脂肪酸，尤其是丁酸，可以促进免疫耐受。

客观的

我们试图确定婴儿早期肠道中细菌丁酸的产生是否对儿童特应性疾病的发展有保护作用。

方法

我们使用shot弹枪宏基因组学分析来确定在婴儿发生过敏性疾病之前，是否可以在婴儿中识别出丁酸发酵中的营养不良。

结果

我们发现，在儿童期后期继续发展过敏性致敏作用的婴儿的微生物组中，缺少编码碳水化合物分解和丁酸生成的关键酶的基因。

结论

我们的发现支持婴儿期早期微生物碳水化合物代谢在预防过敏症发展中的重要性。