Aberrant gene expression underlies drug addiction. Therefore, studying the regulation of gene expression in drug addiction may provide mechanistic insights into this disease, for which there are still only limited treatments. Recently, the three-dimensional (3D) organization of linear DNA in the nucleus has been recognized as having a major influence on gene transcription. Here, we review its roles in both basic brain function and neuropsychiatric disorders, while also highlighting its emerging implications in drug addiction. Unraveling the 3D architecture of chromosomes in drug addiction is adding to our understanding of this disease and has the potential to trigger novel approaches for better diagnosis and therapy.

中文翻译：

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三维染色体结构和药物成瘾。

异常的基因表达是药物成瘾的基础。因此，研究药物成瘾中基因表达的调控可能会提供对该疾病的机理性见解，对此疾病仍然只有有限的治疗方法。最近，人们已经认识到核中线性DNA的三维（3D）组织对基因转录具有重要影响。在这里，我们回顾了它在基本脑功能和神经精神疾病中的作用，同时也突出了它在药物成瘾中的新兴含义。揭开吸毒成瘾的染色体的3D结构，这加深了我们对这种疾病的了解，并有可能触发新颖的方法来更好地诊断和治疗。