Bacterial meningitis is a medical emergency requiring highly bactericidal antibiotics to achieve cure. Many challenges exist to achieving optimal patient outcome. First, antibiotics must pass the blood brain barrier. Once in the subarachnoid space, achieving bactericidal therapy involves circumventing antibiotic resistance and, more commonly, antibiotic tolerance arising from the slow growth of bacteria in the nutrient poor cerebrospinal fluid. Finally, bactericidal therapy is most often bacteriolytic, and debris from lysis is highly inflammatory. Controlling damage from lytic products may require adjunctive therapy to prevent neuronal death. These challenges are an extreme example of the different requirements for treating infections in different body sites.

中文翻译：

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急性细菌性脑膜炎：更好的抗生素治疗的挑战。

细菌性脑膜炎是一种医疗急症，需要高度杀菌的抗生素才能治愈。实现最佳患者结果存在许多挑战。首先，抗生素必须通过血脑屏障。一旦进入蛛网膜下腔，实现杀菌治疗就包括规避抗生素耐药性，更常见的是，由于营养不良的脑脊液中细菌的缓慢生长而引起的抗生素耐受性。最后，杀菌疗法最常见的是溶菌作用，而裂解产生的碎片则具有很高的发炎性。控制裂解产物造成的损害可能需要辅助治疗，以防止神经元死亡。这些挑战是治疗不同身体部位感染的不同要求的一个极端例子。