Germline‐encoded innate immune pattern recognition receptors (PRR) are expressed at epithelial surfaces and modulate epithelial defenses. Evidence suggests that stimulation of the Toll‐like receptor (TLR) family of PRR may regulate epithelial barrier integrity by upregulating tight junction (TJ) complex protein expression, but it is not known whether this mechanism is utilized in esophageal epithelial cells. TJ complex proteins maintain intact barrier function and are dysregulated in atopic disorders including eosinophilic esophagitis.

中文翻译：

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Toll 样受体 2 刺激增强食管屏障完整性

种系编码的先天免疫模式识别受体 (PRR) 在上皮表面表达并调节上皮防御。有证据表明，刺激 PRR 的 Toll 样受体 (TLR) 家族可能通过上调紧密连接 (TJ) 复合蛋白表达来调节上皮屏障完整性，但尚不清楚这种机制是否用于食管上皮细胞。TJ 复合蛋白保持完整的屏障功能，并且在包括嗜酸性粒细胞性食管炎在内的特应性疾病中失调。