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Atypical Functional Connectivity In Tourette Syndrome differs between Children and Adults
Biological Psychiatry ( IF 10.6 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.biopsych.2019.06.021
Ashley N Nielsen 1 , Caterina Gratton 2 , Jessica A Church 3 , Nico U F Dosenbach 4 , Kevin J Black 5 , Steven E Petersen 6 , Bradley L Schlaggar 7 , Deanna J Greene 8
Affiliation  

BACKGROUND Tourette syndrome (TS) is a neuropsychiatric disorder with symptomatology that typically changes over development. Whether and how brain function in TS also differs across development has been largely understudied. Here, we used functional connectivity magnetic resonance imaging to examine whole-brain functional networks in children and adults with TS. METHODS Multivariate classification methods were used to find patterns among functional connections that distinguish individuals with TS from control subjects separately for children and adults (N = 202). We tested whether the patterns of connections that classify diagnosis in one age group (e.g., children) could classify diagnosis in another age group (e.g., adults). We also tested whether the developmental trajectory of these connections was altered in TS. RESULTS Diagnostic classification was successful in children and adults separately but expressly did not generalize across age groups, suggesting that the patterns of functional connections that best distinguished individuals with TS from control subjects were age specific. Developmental patterns among these functional connections used for diagnostic classification deviated from typical development. Brain networks in childhood TS appeared "older" and brain networks in adulthood TS appeared "younger" in comparison with typically developing individuals. CONCLUSIONS Our results demonstrate that brain networks are differentially altered in children and adults with TS. The observed developmental trajectory of affected connections is consistent with theories of accelerated and/or delayed maturation, but may also involve anomalous developmental pathways. These findings further our understanding of neurodevelopmental trajectories in TS and carry implications for future applications aimed at predicting the clinical course of TS in individuals over development.

中文翻译:

图雷特综合征的非典型功能连接在儿童和成人之间有所不同

背景图雷特综合征 (TS) 是一种神经精神疾病,其症状通常会随着发育而改变。TS 中的大脑功能是否以及如何在整个发育过程中也不同,在很大程度上尚未得到充分研究。在这里,我们使用功能连接磁共振成像来检查患有 TS 的儿童和成人的全脑功能网络。方法 多变量分类方法用于寻找功能连接之间的模式,这些模式将儿童和成人(N = 202)的 TS 个体与对照受试者区分开来。我们测试了在一个年龄组(例如,儿童)中对诊断进行分类的连接模式是否可以对另一个年龄组(例如,成人)中的诊断进行分类。我们还测试了这些连接的发展轨迹是否在 TS 中发生了改变。结果 诊断分类在儿童和成人中分别是成功的,但明确没有在年龄组中推广,这表明最能区分患有 TS 的个体与对照受试者的功能连接模式是特定于年龄的。这些用于诊断分类的功能连接之间的发育模式偏离了典型的发育。与典型发育中的个体相比,童年 TS 中的大脑网络显得“更老”,而成年 TS 中的大脑网络显得“更年轻”。结论 我们的结果表明,患有 TS 的儿童和成人的大脑网络发生了不同的改变。观察到的受影响连接的发育轨迹与加速和/或延迟成熟的理论一致,但也可能涉及异常的发育途径。这些发现进一步加深了我们对 TS 中神经发育轨迹的理解,并对未来旨在预测个体过度发育的 TS 临床过程的应用具有意义。
更新日期:2020-01-01
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