Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration,Alzheimer's & Dementia

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Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.jalz.2019.04.007
Adam M Staffaroni ₁ , Yann Cobigo ₁ , Sheng-Yang M Goh ₁ , John Kornak ₂ , Lynn Bajorek ₁ , Kevin Chiang ₁ , Brian Appleby ₃ , Jessica Bove ₄ , Yvette Bordelon ₅ , Patrick Brannelly ₆ , Danielle Brushaber ₇ , Christina Caso ₈ , Giovanni Coppola _{5,

9} , Reilly Dever ₁ , Christina Dheel ₁₀ , Bradford C Dickerson ₁₁ , Susan Dickinson ₁₂ , Sophia Dominguez ₄ , Kimiko Domoto-Reilly ₈ , Kelly Faber ₁₃ , Jessica Ferrall ₁₄ , Julie A Fields ₁₅ , Ann Fishman ₁₆ , Jamie Fong ₁ , Tatiana Foroud ₁₃ , Leah K Forsberg ₁₀ , Ralitza Gavrilova ₁₀ , Debra Gearhart ₁₀ , Behnaz Ghazanfari _{17,

18} , Nupur Ghoshal ₁₉ , Jill Goldman _{20,

21} , Jonathan Graff-Radford ₁₀ , Neill Graff-Radford ₂₂ , Ian Grant ₂₃ , Murray Grossman ₄ , Dana Haley ₂₂ , Hilary W Heuer ₁ , Ging-Yuek Hsiung ₂₄ , Edward D Huey _{20,

21} , David J Irwin ₄ , David T Jones ₁₀ , Lynne Jones ₂₅ , Kejal Kantarci ₂₆ , Anna Karydas ₁ , Daniel I Kaufer ₁₄ , Diana R Kerwin _{27,

28} , David S Knopman ₁₀ , Ruth Kraft ₁₀ , Joel H Kramer ₁ , Walter K Kremers ₇ , Walter A Kukull ₂₉ , Irene Litvan ₃₀ , Peter A Ljubenkov ₁ , Diane Lucente ₁₁ , Codrin Lungu ₃₁ , Ian R Mackenzie ₃₂ , Miranda Maldonado ₅ , Masood Manoochehri ₂₀ , Scott M McGinnis ₁₁ , Emily McKinley ₃₃ , Mario F Mendez _{5,

9} , Bruce L Miller ₁ , Namita Multani _{17,

18} , Chiadi Onyike ₃₄ , Jaya Padmanabhan ₁₁ , Alex Pantelyat ₃₅ , Rodney Pearlman ₃₆ , Len Petrucelli ₃₇ , Madeline Potter ₁₃ , Rosa Rademakers ₃₇ , Eliana Marisa Ramos ₉ , Katherine P Rankin ₁ , Katya Rascovsky ₄ , Erik D Roberson ₃₃ , Emily Rogalski ₃₈ , Pheth Sengdy ₂₄ , Leslie M Shaw ₃₉ , Jeremy Syrjanen ₇ , M Carmela Tartaglia _{17,

18} , Nadine Tatton ₁₂ , Joanne Taylor ₁ , Arthur Toga ₄₀ , John Q Trojanowski ₃₉ , Sandra Weintraub ₂₃ , Ping Wang ₁ , Bonnie Wong ₁₁ , Zbigniew Wszolek ₂₂ , Adam L Boxer ₁ , Brad F Boeve ₁₀ , Howard J Rosen ₁ ,

Affiliation

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA.
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco CA, USA Department of Neurology, Memory and Aging Center.
Department of Neurology, Case Western Reserve University, Cleveland, OH, USA University of California, San Francisco, San Francisco CA, USA.
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Epidemiology and Biostatistics.
Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA Case Western Reserve University, Cleveland, OH, USA.
Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA Department of Neurology.
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA University of Pennsylvania, Philadelphia, PA, USA.
Department of Neurology, University of Washington, Seattle, WA, USA Perelman School of Medicine, Department of Neurology.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA University of California, Los Angeles, Los Angeles, CA, USA.
Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology.
Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA.
Association for Frontotemporal Degeneration, Radnor, PA, USA Mayo Clinic, Rochester, MN, USA.
National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA.
Department of Neurology, University of North Carolina, Chapel Hill, NC, USA University of Washington, Seattle, WA, USA.
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA School of Medicine, Department of Psychiatry.
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada University of California, Los Angeles, Los Angeles, CA, USA.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Departments of Neurology and Psychiatry, Washington University School of Medicine, Washington University, St. Louis, MO, USA Mayo Clinic, Rochester, MN, USA.
Department of Neurology, Columbia University, New York, NY, USA Department of Neurology.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA Association for Frontotemporal Degeneration, Radnor, PA, USA.
Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA.
Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada University of North Carolina, Chapel Hill, NC, USA.
Department of Radiology, Washington University School of Medicine, Washington University, St. Louis, MO, USA Johns Hopkins University, Baltimore, MD, USA.
Department of Radiology, Mayo Clinic, Rochester, MN, USA Department of Radiology.
Department of Neurology and Neurotherapeutics, Center for Alzheimer's and Neurodegenerative Diseases, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto.
Department of Internal Medicine, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA Division of Neurology, Department of Medicine, University of Toronto.
National Alzheimer Coordinating Center (NACC), University of Washington, Seattle, WA, USA Washington University, St. Louis, MO, USA.
Department of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, San Diego, CA, USA Department of Neurosciences, Parkinson and Other Movement Disorders Center.
National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA Columbia University, New York, NY, USA.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Neurology, Alzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA Columbia University, New York, NY, USA.
Department of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University, Baltimore, MD, USA Department of Geriatric Psychiatry and Neuropsychiatry.
Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA Mayo Clinic, Jacksonville, FL, USA.
Bluefield Project, San Francisco, CA, USA Bluefield Project, San Francisco, CA, USA.
Department of Neurosciences, Mayo Clinic, Jacksonville, FL, USA Northwestern University, Chicago, IL, USA.
Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA University of British Columbia, Vancouver, British Columbia, Canada.
Departments of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering, Laboratory of Neuroimaging (LONI), USC, Los Angeles, CA, USA Laboratory of Neuroimaging (LONI), Departments of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering.

Some models of therapy for neurodegenerative diseases envision starting treatment before symptoms develop. Demonstrating that such treatments are effective requires accurate knowledge of when symptoms would have started without treatment. Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset.

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