Data sources Medline, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus, Web of Knowledge, Virtual Health Library, Google Scholar and ISRCTN registry databases.Study selection Randomised controlled trials (RCTs) and prospective or retrospective non-randomised clinical trials on periodontal healthy human patients receiving comprehensive fixed appliance treatment were considered.Data extraction and synthesis Two reviewers independently extracted data and assessed risk of bias using either the Cochrane tool for RCTs or the ROBINS-I (Risk Of Bias In Non-randomised Studies - of Interventions) tool for non-randomised studies. A Paule-Mandel random-effects meta-analyses was conducted for clinical attachment loss. Results Nine prospective non-randomised trials involving a total of 335 periodontally healthy patients were included. The patients' average age was 22.6 years (range 11.4 - 42.1 years). Seven of the nine studies were assessed as being at moderate risk of bias. Orthodontic treatment was associated with a mean clinical attachment loss of 0.11 mm (95 %CI: 0.12 mm gain to 0.34 mm loss; P = 0.338, I2 = 99.6%), which was neither statistically nor clinically significant.Conclusions The findings suggest that orthodontic treatment might have little or no clinically relevant detrimental effect on the clinical attachment levels of patients.

中文翻译：

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固定的正畸治疗对临床依从性水平影响不大。

数据来源Medline，Embase，Cochrane对照试验中心注册，Cochrane系统评价数据库，Scopus，知识网络，虚拟健康图书馆，Google Scholar和ISRCTN注册数据库。研究选择随机对照试验（RCT）和前瞻性或回顾性非回顾性研究。考虑了接受综合固定装置治疗的牙周健康人类患者的随机临床试验。数据提取和综合两名评价员独立提取数据并使用Cochrane随机对照试验工具或ROBINS-I评估偏倚风险（非随机偏倚风险）研究-干预）工具用于非随机研究。进行了Paule-Mandel随机效应荟萃分析以评估临床依从性丧失。结果纳入9项前瞻性非随机试验，涉及总共335名牙周健康患者。患者的平均年龄为22.6岁（范围11.4-42.1岁）。九项研究中的七项被评估为处于中等偏见风险。正畸治疗的平均临床附着丧失为0.11 mm（95％CI：0.12 mm增至0.34 mm丧失; P = 0.338，I2 = 99.6％），这在统计学和临床​​上均无统计学意义。治疗可能对患者的临床依恋程度几乎没有或没有临床相关的有害影响。