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New Horizons in Acetogenic Conversion of One-Carbon Substrates and Biological Hydrogen Storage.
Trends in Biotechnology ( IF 17.3 ) Pub Date : 2019-06-27 , DOI: 10.1016/j.tibtech.2019.05.008
Volker Müller 1
Affiliation  

Strictly anaerobic, acetogenic (acetate-forming) bacteria are characterized by a reductive pathway in which two mol of CO2 are reduced to one mol of acetyl coenzyme A (acetyl-CoA) and then further to acetate, ethanol, or butyrate. Therefore, they have come into focus for an alternative, CO2-based bioeconomy. Other one-carbon (C1) substrates, such as formic acid or methanol, are promising feedstocks for an alternative bioeconomy using acetogens as biocatalysts that have been somewhat overlooked. In addition, acetogens, such as Acetobacterium woodii and Thermoanaerobacter kivui, have a unique enzyme system capable of reducing CO2 to formate with H2 as reductant that is superior over any chemical catalyst for CO2-based hydrogen storage. Therefore, acetogens are also promising candidates in the hydrogen economy as potential catalysts for hydrogen storage or production.

中文翻译:

单碳底物的成乙酸转化和生物储氢的新视野。

严格厌氧的产乙酸(乙酸盐形成)细菌的特征在于还原途径,其中将2摩尔的CO2还原为1摩尔的乙酰辅酶A(乙酰-CoA),然后进一步还原为乙酸盐,乙醇或丁酸盐。因此,它们已成为基于CO2的替代生物经济的焦点。其他的一碳(C1)底物,例如甲酸或甲醇,是有希望的原料,可替代使用乙炔作为生物催化剂的生物经济替代品,而这一点已被人们忽略了。另外,诸如木醋杆菌和基热厌氧菌的产乙酸酶具有独特的酶系统,该系统能够将CO2还原成H2作为还原剂,其性能优于任何基于CO2的氢存储的化学催化剂。所以,
更新日期:2019-11-18
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