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Proinsulin associates with poor β-cell function, glucose-dependent insulinotropic peptide, and insulin resistance in persistent type 2 diabetes after Roux-en-Y gastric bypass in humans.
Journal of Diabetes ( IF 4.5 ) Pub Date : 2019-07-24 , DOI: 10.1111/1753-0407.12964
Kapila Patel 1 , Kiarra Levesque 1 , Victoria Mark 1 , Esmeralda Pierini 1 , Betsy Rojas 1 , Michael Ahlers 1 , Ankit Shah 2 , Blandine Laferrère 1, 2
Affiliation  

The determinants of type 2 diabetes (T2D) remission and/or relapse after gastric bypass (RYGB) remain fully unknown. This study characterized β‐ and α‐cell function, in cretin hormone release and insulin sensitivity in individuals with (remitters) or without (non‐remitters) diabetes remission after RYGB.

中文翻译:

胰岛素原与人类 Roux-en-Y 胃绕道手术后持续性 2 型糖尿病的 β 细胞功能不良、葡萄糖依赖性促胰岛素肽和胰岛素抵抗有关。

胃绕道手术 (RYGB) 后 2 型糖尿病 (T2D) 缓解和/或复发的决定因素仍然完全未知。本研究描述了 RYGB 后糖尿病缓解(缓解者)或未缓解(非缓解者)个体的 β 细胞和 α 细胞功能、克汀激素释放和胰岛素敏感性。
更新日期:2019-07-24
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