BACKGROUND Multiparametric magnetic resonance imaging (MP-MRI) targeted biopsy has been shown to identify more clinically-significant cancers and reduce the detection of clinically-insignificant disease when compared to systematic biopsy; however, the wide-spread accessibility of MP-MRI is limited. A potential strategy for reducing the cost, study time, and contrast-associated risks associated with MP-MRI is elimination of the dynamic contrast-enhanced (DCE) sequence, relying instead on biparametric MRI (BP-MRI). BP-MRI has been shown to have a diagnostic accuracy and cancer detection rate that are equivalent to those of MP-MRI. METHODS We modeled the potential cost of BP-MRI compared to MP-MRI to determine what cost savings would occur if DCE was eliminated from these studies. RESULTS When controlled for a 45 min time window that allows for one full MP-MRI or three full BP-MRI studies, the BP-MRI 45 min gross profit is $1531.32. This is an increase in gross profit of $892.58 for the 45 min time window or $10,710.98 in a 9-h business day when performing BP-MRI compared to MP-MRI for prostate cancer detection. CONCLUSIONS BP-MRI has the potential to result in substantial cost benefit and increased access to MRI in the diagnostic workflow and risk-stratification of men being evaluated for prostate cancer when compared to conventional MP-MRI.

中文翻译：

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双参数前列腺MRI的财务影响。

背景技术与系统活检相比，多参数磁共振成像（MP-MRI）靶向活检已显示出可识别更多具有临床意义的癌症，并减少了对临床意义不重大的疾病的检测。但是，MP-MRI的广泛使用受到了限制。减少与MP-MRI相关的成本，研究时间和与造影剂相关的风险的潜在策略是消除动态造影剂（DCE）序列，而改为依靠双参数MRI（BP-MRI）。BP-MRI已显示出与MP-MRI相当的诊断准确性和癌症检出率。方法我们对BP-MRI与MP-MRI相比的潜在成本进行了建模，以确定如果从这些研究中消除DCE可以节省多少成本。结果如果在45分钟的时间范围内进行控制，可以进行一次完整的MP-MRI或三个完整的BP-MRI研究，则BP-MRI的45分钟毛利润为$ 1531.32。与使用MP-MRI进行前列腺癌检测相比，在45分钟的时间范围内，执行BP-MRI的毛利润增加了892.58美元，在9小时的工作日内增加了10,710.98美元。结论与传统的MP-MRI相比，BP-MRI有可能在诊断工作流程中带来实质性的成本优势并增加MRI的获取机会，并对男性进行前列腺癌的风险分层。