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Alterations of cerebral perfusion and functional brain connectivity in medication-naïve male adults with attention-deficit/hyperactivity disorder.
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2019-06-23 , DOI: 10.1111/cns.13185
Ya-Wen Tan 1, 2 , Lu Liu 1, 2 , Yan-Fei Wang 1, 2 , Hai-Mei Li 1, 2 , Mei-Rong Pan 1, 2 , Meng-Jie Zhao 1, 2 , Fang Huang 1, 2 , Yu-Feng Wang 1, 2 , Yong He 3, 4 , Xu-Hong Liao 5 , Qiu-Jin Qian 1, 2
Affiliation  

AIMS Functional brain abnormalities, including altered cerebral perfusion and functional connectivities, have been illustrated in adults with attention-deficit/hyperactivity disorder (aADHD). The present study attempted to explore the alterations of cerebral blood flow (CBF) and resting-state functional connectivity (RSFC) simultaneously to understand the neural mechanisms for adults with ADHD comprehensively. METHODS Resting-state arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) data were acquired for 69 male aADHD and 69 matched healthy controls (HCs). The altered CBFs associated with aADHD were explored based on both categorical (aADHD vs HCs) and dimensional (correlation with aADHD core symptoms) perspectives. Then, the seed-based RSFC analyses were developed for the regions showing significant alterations of CBF. RESULTS Significantly decreased CBF in the large-scale resting-state networks regions (eg, ventral attentional network, somatomotor network, limbic network) and subcortical regions was indicated in aADHD compared with HCs. The correlation analyses indicated that the hypoperfusion in left putamen/global pallidum and left amygdala/hippocampus was correlated with ADHD inattentive and total symptoms, respectively. Further, weaker negative functional connectivity between left amygdala and bilateral supplementary motor area, bilateral superior frontal gyrus, and left medial frontal gyrus was found in adults with ADHD. CONCLUSION The present findings suggested alterations of both cerebral perfusion and functional connectivity for the left amygdala in aADHD. The combination of CBF and RSFCs may help to interpret the neuropathogenesis of ADHD more comprehensively.

中文翻译:

患有药物缺乏/多动症的未接受过药物治疗的男性成年人的脑灌注和脑功能连接性改变。

AIMS已在患有注意力缺陷/多动症(aADHD)的成年人中阐明了功能性脑异常,包括脑灌注和功能性连接改变。本研究试图探索脑血流量(CBF)和静止状态功能连接(RSFC)的变化,以全面了解成年人多动症的神经机制。方法采集了69位男性aADHD和69位匹配的健康对照(HCs)的静息状态动脉自旋标记(ASL)和血液氧合水平依赖性(BOLD)磁共振成像(MRI)数据。基于分类(aADHD与HCs)和尺寸(与aADHD核心症状的相关性)观点,探讨了与aADHD相关的CBF改变。然后,针对表现出CBF显着变化的区域,开展了基于种子的RSFC分析。结果在aADHD中,与HC相比,大型静息状态网络区域(例如腹侧注意力网络,躯体运动网络,边缘网络)和皮层下区域的CBF显着降低。相关分析表明,左壳核/全苍白球和左杏仁核/海马的灌注不足分别与注意力不足过动症和总症状相关。此外,在患有ADHD的成年人中,发现左杏仁核和双侧辅助运动区,双侧上额回和左额中回之间较弱的负功能连通性。结论本研究结果提示aADHD中左杏仁核的脑灌注和功能连通性均发生改变。CBF和RSFC的组合可能有助于更全面地解释ADHD的神经发病机制。
更新日期:2019-11-18
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