Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria (aiCSU): Results of the PURIST Study,Allergy

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Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria (aiCSU): Results of the PURIST Study
Allergy ( IF 12.4 ) Pub Date : 2019-07-29 , DOI: 10.1111/all.13949
Nicole Schoepke ₁ , Riccardo Asero ₂ , André Ellrich ₁ , Marta Ferrer ₃ , Ana Gimenez-Arnau ₄ , Clive E H Grattan ₅ , Thilo Jakob _{6,

7} , George N Konstantinou ₈ , Ulrike Raap ₉ , Per Stahl Skov _{10,

11} , Petra Staubach ₁₂ , Arno Kromminga _{13,

14} , Ke Zhang ₁₅ , Carsten Bindslev-Jensen ₁₆ , Alvaro Daschner ₁₇ , Tamar Kinaciyan ₁₈ , Edward F Knol ₁₉ , Michael Makris ₂₀ , Nadine Marrouche ₂₁ , Peter Schmid-Grendelmeier _{22,

23} , Gordon Sussman ₂₄ , Elias Toubi ₂₅ , Martin K Church ₁ , Marcus Maurer ₁

Affiliation

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department of Allergology, Clinica San Carlo, Paderno Dugnano (MI), Italy.
Department of Allergy and Clinical Immunology, Clinica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Pamplona, Spain.
Department of Dermatology, Hospital del Mar, IMIM, Universitat Autònoma Barcelona, Barcelona, Spain.
Guy's Hospital, London, UK.
Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus-Liebig University Gießen, Gießen, Germany.
Allergy Research Group, Medical Center, University of Freiburg, Freiburg, Germany.
Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, Greece.
Department of Human Medicine and Health Sciences, University Clinic of Dermatology and Allergy, University of Oldenburg, Oldenburg, Germany.
RefLab ApS, Copenhagen, Denmark.
Odense Research Center of Anaphylaxis, ORCA, Odense, Denmark.
Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
Bioagilytix Europe GmbH, Hamburg, Germany.
Institute of Immunology, University of Kiel, Kiel, Germany.
Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Servicio de Alergia, Instituto de Investigación Sanitaria (IIS)- Hospital Universitario de la Princesa, Madrid, Spain.
Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
Allergy Unit, 2nd Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.
Allergy Unit, Department of Dermatology, University Hospital, Zürich, Switzerland.
Christine Kühne Center for Allergy Research and Education CK-CARE, Davos, Switzerland.
Division of Allergy and Clinical Immunology, University of Toronto, Toronto, Ontario, Canada.
Faculty of Medicine, Bnai-Zion Medical Center, Technion, Haifa, Israel.

Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of chronic spontaneous urticaria (CSU) in which functional IgG autoantibodies to IgE or its high‐affinity receptor (FcεRI) induces mast cell degranulation and subsequent symptom development. However, it has not been tightly characterized. This study aimed to better define the clinical and immunological features and to explore potential biomarkers of aiCSU.

中文翻译：

自身免疫性慢性自发性荨麻疹 (aiCSU) 的生物标志物和临床特征：PURIST 研究的结果

自身免疫性慢性自发性荨麻疹 (aiCSU) 是慢性自发性荨麻疹 (CSU) 的一个重要亚型，其中针对 IgE 或其高亲和力受体 (FcεRI) 的功能性 IgG 自身抗体诱导肥大细胞脱颗粒和随后的症状发展。然而，它没有被严格表征。本研究旨在更好地定义 aiCSU 的临床和免疫学特征并探索潜在的生物标志物。

更新日期：2019-07-29

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