www.thelancet.com/neurology Published online June 21, 2019 http://dx.doi.org/10.1016/S1474-4422(19)30247-9 1 As the 20 members of the choir took to the stage at the Royal Concert Hall in Nottingham, UK, it wasn’t simply their nerves they’d had to overcome to perform in public. Each member of the choir had dementia and faced the challenge of remembering the lyrics to the songs. Their performance of In My Life by The Beatles was the climax of Our Dementia Choir with Vicky McClure, a two-part documentary first shown on May 2 and 9, 2019, on UK television station BBC One. The programme’s presenter—actress Vicky McClure, best known for her roles in drama series such as Line of Duty and This Is England—has supported the Alzheimer’s Society since helping to care for her Nana Iris, who died from dementia in 2015. The documentary followed McClure over 10 weeks as she recruited singers for the choir and then rehearsed with them. Along the way, the series told the stories of the singers, including: Betty, 82, who has Alzheimer’s disease; Chris, 67, who took early retirement from teaching after being diagnosed with frontotemporal dementia; and Daniel, 31, a former engineer and drummer with early-onset Alzheimer’s disease. As part of the programme, Sebastian Crutch, Professor of Neuropsychology at University College London, UK, studied the singers’ emotional and physiological responses to being in the choir using detailed questionnaires and wrist sen sors, which measured each singers’ heart rate, movement, temperature, and skin conductance before, during, and after rehearsals, as part of the Created Out of Mind research programme funded by the Wellcome Trust. Some members of the choir also took part in brain imaging and other studies, including Daniel, who underwent EEG hyperscanning under the supervision of Jörg Fachner, Professor of Music, Health and the Brain at Anglia Ruskin University in Cambridge, UK. At first, Daniel was unable to drum in time to the beat set by a music therapist, but after a while he could tap along to her beat and then drum along to Use Somebody by Kings of Leon, one of his favourite songs. Four members of the choir, along with McClure, underwent magnetoencephalography at the Sir Peter Mansfield Imaging Centre (SPMIC) at the University of Nottingham, UK, with Crutch and Lauren Gascoyne, a Research Fellow at SPMIC, monitoring how their brain activity changed when they heard different pieces of music. Crutch explained that, regardless of their type of dementia, each participant’s brain responded in the same way to the music. He highlighted the “sheer degree of activity”, which “shows the power of musical stimulation”. The programme also explored the effect music therapy had on people with dementia. McClure visited Eileen Pegg, 91, a resident with advanced Alzheimer’s at a care home in Stafford, UK. Pegg went from being confused and incoherent to singing along with music therapist Chris Wilson, who explained that the frequency of her anxiety responses fell dramatically following music therapy. Pegg’s response echoed the examples used by Andy Lowndes, deputy chair of the Playlist for Life charity, in his talk at the 2019 Edinburgh Science Festival. As well as highlighting the challenge the singers faced in learning lyrics, the programme showed how they benefited from joining the choir, including June, whose daughter said she rarely speaks but who sang all the words to the songs, and Rae, a retired music teacher with Alzheimer’s disease, who gave up playing the piano 10 years earlier but who was able to play Beethoven’s piano sonatas at the first rehearsal, and went on to accompany the choir during subsequent meetings. Crutch’s involvement in the programme was partly motivated by a 2017 review in the International Journal of Psychophysiology, in which he and colleagues highlighted how few studies had looked at physiological responses to arts activities in people with dementia. From the data collected during the series, Crutch and his team concluded that skin conductance might be a helpful measure to gauge responses of people with dementia within a choral programme, and that singing helped the participants to feel better, above and beyond the benefit of social isa tion. Their findings were presented at the 19th International Graphonomics Conference at Cancun, Mexico, on June 11, 2019. Crutch told The Lancet Neurology: “I hope it’s a good starting point for pulling together different techniques that help us under stand the impact arts-based activities have for people living with dementia. Often people rely on one or a small number of metrics to say what has been the impact of something that is multi-component— many activities have a physical, social, psychological, and creative element. “We can hopefully not only understand the broader impact that these activities can have, but we can also be more confident in our interpretation of any one of these individual metrics,” he said. Artists are often interested in the collective benefit to the whole group of projects such as singing, rather than the benefits for any one individual, Crutch pointed out. He added: “Sometimes it feels like traditional scientific metrics—be they qualitative or quantitative—are only a partial reflection of the thing we’re really interested in, that collective benefit.” Since the documentary finished filming in the summer of 2018, the choir has met regularly and continues to perform at events, said Charlie Bunce, executive producer at Curve Media, the company that made the programme.

中文翻译：

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我们的痴呆症合唱团演奏出正确的音符

www.thelancet.com/neurology 2019 年 6 月 21 日在线发布 http://dx.doi.org/10.1016/S1474-4422(19)30247-9 1 合唱团 20 名成员在皇家音乐会上登台在英国诺丁汉的霍尔，他们在公共场合表演不仅仅是必须克服紧张。合唱团的每个成员都患有痴呆症，面临着记住歌曲歌词的挑战。他们在 The Beatles 演唱的 In My Life 是 Our Dementia Choir with Vicky McClure 的高潮，这部由两部分组成的纪录片于 2019 年 5 月 2 日至 9 日在英国电视台 BBC One 首播。该节目的主持人——女演员 Vicky McClure，以其在《使命召唤》和《这就是英格兰》等系列剧中的角色而闻名——自从帮助照顾她于 2015 年死于痴呆症的 Nana Iris 以来，一直支持阿尔茨海默氏症协会。这部纪录片跟踪麦​​克卢尔超过 10 周，她为合唱团招募歌手，然后与他们一起排练。一路上，该系列讲述了歌手的故事，包括： 贝蒂，82 岁，患有阿尔茨海默病；克里斯，67 岁，在被诊断出患有额颞叶痴呆后提前退休；丹尼尔，31 岁，前工程师和鼓手，患有早发性阿尔茨海默病。作为该计划的一部分，英国伦敦大学学院神经心理学教授 Sebastian Crutch 使用详细的问卷和手腕传感器研究了歌手在合唱团中的情绪和生理反应，后者测量了每位歌手的心率、运动、作为 Wellcome Trust 资助的 Created Out of Mind 研究计划的一部分，在排练之前、之中和之后的温度和皮肤电导。合唱团的一些成员还参与了大脑成像和其他研究，包括 Daniel，他在英国剑桥安格利亚鲁斯金大学音乐、健康和大脑教授 Jörg Fachner 的监督下接受了脑电图超扫描。起初，丹尼尔无法及时按照音乐治疗师设定的节拍敲鼓，但过了一会儿，他可以随着她的节拍敲鼓，然后随着莱昂国王的《Use Somebody》而鼓，这是他最喜欢的歌曲之一。合唱团的四名成员与麦克卢尔一起在英国诺丁汉大学的彼得曼斯菲尔德爵士成像中心 (SPMIC) 接受了脑磁图检查，并与 Crutch 和 SPMIC 的研究员 Lauren Gascoyne 一起监测了他们的大脑活动如何变化听到了不同的音乐片段。Crutch 解释说，无论他们患有何种类型的痴呆症，每个参与者的大脑以相同的方式对音乐做出反应。他强调了“纯粹的活动程度”，“展示了音乐刺激的力量”。该计划还探讨了音乐疗法对痴呆症患者的影响。麦克卢尔拜访了 91 岁的艾琳佩格，她是英国斯塔福德一家养老院的老年痴呆症患者。Pegg 从困惑和语无伦次到与音乐治疗师 Chris Wilson 一起唱歌，后者解释说，在音乐治疗后，她的焦虑反应频率急剧下降。Pegg 的回应与 Playlist for Life 慈善机构副主席 Andy Lowndes 在 2019 年爱丁堡科学节上的演讲中使用的例子相呼应。除了强调歌手在学习歌词方面所面临的挑战之外，该节目还展示了他们如何从加入合唱团中受益，包括六月、她的女儿说她很少说话，但她把歌曲的所有词都唱了出来，还有 Rae，一位患有阿尔茨海默病的退休音乐教师，10 年前放弃弹钢琴，但在第一次排练时能够演奏贝多芬的钢琴奏鸣曲，并在随后的会议中继续陪伴合唱团。Crutch 参与该计划的部分动机是 2017 年发表在《国际心理生理学杂志》上的一篇评论，其中他和同事强调了很少有研究关注痴呆症患者对艺术活动的生理反应。从系列期间收集的数据中，Crutch 和他的团队得出结论，皮肤电导可能是衡量痴呆症患者在合唱计划中的反应的有用措施，并且唱歌有助于参与者感觉更好，超越社会化的好处。他们的研究结果于 2019 年 6 月 11 日在墨西哥坎昆举行的第 19 届国际图形学会议上发表。 Crutch 告诉柳叶刀神经病学：“我希望这是一个很好的起点，可以将不同的技术结合在一起，帮助我们理解基于艺术的影响活动针对痴呆症患者。人们通常依赖一个或少数几个指标来说明多因素事物的影响——许多活动都具有身体、社会、心理和创造性的元素。“我们希望不仅可以了解这些活动可能产生的更广泛的影响，而且我们还可以对我们对这些单独指标中的任何一个的解释更有信心，”他说。Crutch 指出，艺术家们通常对整个项目组的集体利益感兴趣，例如唱歌，而不是对任何个人的利益。他补充说：“有时感觉就像传统的科学指标——无论是定性的还是定量的——只是我们真正感兴趣的事情的部分反映，即集体利益。” 制作该节目的公司 Curve Media 的执行制片人查理·邦斯 (Charlie Bunce) 表示，自纪录片于 2018 年夏天完成拍摄以来，合唱团定期会面并继续在活动中表演。那种集体利益。” 制作该节目的公司 Curve Media 的执行制片人查理·邦斯 (Charlie Bunce) 表示，自纪录片于 2018 年夏天完成拍摄以来，合唱团定期会面并继续在活动中表演。那种集体利益。” 制作该节目的公司 Curve Media 的执行制片人查理·邦斯 (Charlie Bunce) 表示，自纪录片于 2018 年夏天完成拍摄以来，合唱团定期会面并继续在活动中表演。