It is recognized that donor factors contribute to lung transplant outcomes. Recent observations and studies have started to elucidate potential mechanisms behind explaining these observations. This perspective piece summarizes evolving lung transplant literature on the subject, focusing on donor “passenger” organisms, cells, hormones, and proteins transferred to the recipient. Many extrinsic and intrinsic donor features or properties have important consequences for subsequent allograft function in the recipient. Potentially, a better understanding of these features may provide useful novel therapeutic targets to enhance allograft outcomes.

中文翻译：

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供体来源的乘客（病原体，细胞，生物分子和蛋白质）对临床结果的影响。

公认供体因素有助于肺移植的结果。最近的观察和研究已经开始阐明解释这些观察结果的潜在机制。该观点文章总结了有关该主题的不断发展的肺移植文献，重点讨论了转移至受体的供体“乘客”生物，细胞，激素和蛋白质。许多外在的和内在的供体特征或特性对受体随后的同种异体移植功能都有重要的影响。潜在地，对这些特征的更好理解可能会提供有用的新型治疗靶点，以增强同种异体移植的效果。