The phenotypic diversity of cortical GABAergic neurons is probably necessary for their functional versatility in shaping the spatiotemporal dynamics of neural circuit operations underlying cognition. Deciphering the logic of this diversity requires comprehensive analysis of multi-modal cell features and a framework of neuronal identity that reflects biological mechanisms and principles. Recent high-throughput single-cell analyses have generated unprecedented data sets characterizing the transcriptomes, morphology and electrophysiology of interneurons. We posit that cardinal interneuron types can be defined by their synaptic communication properties, which are encoded in key transcriptional signatures. This conceptual framework integrates multi-modal cell features, captures neuronal input-output properties fundamental to circuit operation and may advance understanding of the appropriate granularity of neuron types, towards a biologically grounded and operationally useful interneuron taxonomy.

中文翻译：

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GABA能神经元和神经通讯元件的多样性。

皮质 GABA 能神经元的表型多样性可能是它们在塑造认知基础神经回路操作的时空动态方面的多功能性所必需的。破译这种多样性的逻辑需要全面分析多模式细胞特征和反映生物学机制和原理的神经元身份框架。最近的高通量单细胞分析产生了前所未有的数据集，这些数据集表征了中间神经元的转录组、形态学和电生理学。我们假设主要的中间神经元类型可以通过它们的突触通信特性来定义，这些特性被编码在关键的转录签名中。这个概念框架集成了多模态细胞特征，